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Formulation, which can be administered gastrointestinally, and uses thereof

A gastrointestinal and preparation technology, applied in the direction of drug combinations, surgical drugs, medical preparations containing active ingredients, etc., can solve the life-threatening problems of surgical patients

Inactive Publication Date: 2008-02-13
FRESENIUS KABI DEUT GMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So-called ischemia / reperfusion phenomenon can lead to life-threatening condition in surgical patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0083] The following examples are intended to illustrate the invention without limiting it.

[0084] ischemia-reperfusion model

[0085] Every surgical procedure involves reversible ischemia of organs and tissues caused by the temporary clamping of blood vessels. This ischemic condition can be mimicked in a "low-flow, high-flow" hepatic perfusion model in rats.

[0086] In this rat model, the liver is perfused at a low flow rate to produce a localized oxygen deficiency, ie, hypoxia, in the pericentral hepatic zone through reduced oxygen supply. Subsequent reperfusion of the liver at normal flow rates brings oxygen back to previously hypoxic hepatic regions, which then leads to the formation of oxygen-dependent free radicals and consequent reperfusion injury. Much of the resulting cell death in the pericentral hepatic zone releases cell-bound enzymes, such as lactate hydrogenase and transaminases, which can be detected and quantified in the perfusate.

[0087] Sprague-Dawley...

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PUM

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Abstract

A formulation which can be administered gastrointestinally and comprises green tea extract and at least one NO donor which is a substrate of NO synthetase, and / or a precursor thereof is described. The formulation is administered before surgical procedures, in order to avert or reduce the risk of postoperative complications.

Description

technical field [0001] The present invention relates to pharmaceutical or nutritional preparations which can be administered gastrointestinally and to their use for preventing or reducing the risk of postoperative complications. Background technique [0002] Major surgical procedures must often be expected to be accompanied by postoperative morbidity. The complication can have various symptoms, but is often due to insufficient blood supply to the tissues involved in the procedure. The so-called ischemia / reperfusion phenomenon can lead to life-threatening conditions in surgical patients. [0003] To date, such complications are mainly treated only after they have occurred. [0004] However, it is also described in the literature that patients are prepared by taking selected preparations before surgery to reduce the risk or impact of postoperative complications. [0005] US-A 5 656 608 thus describes a method of treating endotoxemia comprising administering an effective amo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/04A61P41/00A61K36/82A61K31/198
CPCA61K36/82A61K31/04A61K31/198A61P41/00A61P43/00A61P9/08A61P9/10A61K2300/00
Inventor H·施奈德
Owner FRESENIUS KABI DEUT GMBH