Oral quick release preparation of indinavir, and preparing method
A technology for indinavir and immediate-release preparations is applied in the field of oral indinavir preparations and preparations, and can solve the problems of retention, large doses of anti-AIDS drugs, and difficulty in swallowing drugs.
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Embodiment 1
[0088] prescription:
[0089] Composition Weight percentage content
[0090] Indinavir 15%
[0091] cCMS-Na 6%
[0092] PVP (1% aqueous solution) 1%
[0093] Magnesium Stearate 0.5%
[0094] The rest is lactose added to 100%
[0095] Preparation:
[0096] First crush the above materials through a 100-mesh sieve, mix indinavir, lactose, and cCMS-Na evenly, use 1% PVP aqueous solution as a binder, make a soft material, pass through a 20-mesh sieve to granulate, and dry at 80°C , 20 mesh whole grains, added magnesium stearate, mixed evenly, and compressed into tablets.
Embodiment 2
[0098] prescription:
[0099] Composition Weight percentage content
[0100] Indinavir 15%
[0101] CMS-Na 6%
[0102] PVP (1% aqueous solution) 1%
[0103] Magnesium Stearate 0.5%
[0104] The rest is mannitol added to 100%
[0105] Preparation:
[0106] Firstly, the above materials were crushed through a 100-mesh sieve, and indinavir, mannitol, and 60% CMS-Na were mixed evenly, and 1% PVP aqueous solution was used as a binder to make a soft material, and granulated through a 20-mesh sieve, 80 Dry at ℃, granulate at 20 meshes, add remaining 40% CMS-Na and magnesium stearate, mix evenly, and press into tablets.
Embodiment 3
[0108] Prescription weight percentage content
[0109] Indinavir 10%
[0110] Pregelatinized Starch 20%
[0111] Microcrystalline Cellulose 10%
[0112] LHPC 6%
[0113] PVP (1% aqueous solution) 1%
[0114] Magnesium Stearate 0.5%
[0115]The rest is lactose added to 100%
[0116] Preparation:
[0117] First crush the above materials through a 100-mesh sieve, mix indinavir, lactose, pregelatinized starch, microcrystalline cellulose, and LHPC evenly, use 1% PVP aqueous solution as a binder, make a soft material, and pass through a 20-mesh Sieve and granulate, dry at 80°C, granulate with 20 meshes, add magnesium stearate, mix evenly, and tablet.
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