Oral preparation of quick releasing stavudine, and producing method

A technology for stavudine and immediate-release preparations, which can be used in pill delivery, antiviral agents, and pharmaceutical formulations, and can solve problems such as retention, difficulty in swallowing drugs, and discomfort

Inactive Publication Date: 2008-11-26
中科医药行业生产力促进中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The dosage of antiviral drugs, especially anti-AIDS drugs, is generally large and needs to be taken for a long time. The common dosage forms currently on the market cannot meet the needs of the market, for example; Weaker elderly and children are reluctant to take these solid formulations and complain of difficulty swallowing or blockage of the esophagus
As far as powders and granules are concerned, they are also prone to stagnation in the mouth, causing unpleasant sensations in the mouth, and at the same time, drinking water is required when taking the above preparations, which brings a lot of inconvenience

Method used

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  • Oral preparation of quick releasing stavudine, and producing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0083] prescription:

[0084] Composition Weight percentage content

[0085] Stavudine 5%

[0086] cCMS-Na 6%

[0087] PVP (1% aqueous solution) 1%

[0088] Magnesium Stearate 0.5%

[0089] The rest is lactose added to 100%

[0090] Preparation:

[0091] First, the above-mentioned materials were crushed through a 100-mesh sieve, and stavudine, lactose, and cCMS-Na were mixed evenly, and 1% PVP aqueous solution was used as a binder to make a soft material, granulated through a 20-mesh sieve, and dried at 80°C. The 20-mesh granule is added with magnesium stearate, mixed evenly, and compressed into tablets.

Embodiment 2

[0093] prescription:

[0094] Composition Weight percentage content

[0095] Stavudine 5%

[0096] CMS-Na 6%

[0097] PVP (1% aqueous solution) 1%

[0098] Magnesium Stearate 0.5%

[0099] The rest is mannitol added to 100%

[0100] Preparation:

[0101] First crush the above materials through a 100-mesh sieve, mix stavudine, mannitol, and 60% CMS-Na evenly, use 1% PVP aqueous solution as a binder, make a soft material, pass through a 20-mesh sieve, and granulate at 80°C Dried, granulated in 20 meshes, added the remaining 40% CMS-Na and magnesium stearate, mixed evenly, and pressed into tablets.

Embodiment 3

[0103] Prescription weight percentage content

[0104] Stavudine 3.5%

[0105] Pregelatinized Starch 20%

[0106] Microcrystalline Cellulose 10%

[0107] LHPC 6%

[0108] PVP (1% aqueous solution) 1%

[0109] Magnesium Stearate 0.5%

[0110] The rest is lactose added to 100%

[0111] Preparation:

[0112]First, crush the above materials respectively through a 100-mesh sieve, mix stavudine, lactose, pregelatinized starch, microcrystalline cellulose, and LHPC evenly, use 1% PVP aqueous solution as a binder, make a soft material, and pass through a 20-mesh sieve Granulate, dry at 80°C, granulate into 20 meshes, add magnesium stearate, mix evenly, and compress into tablets.

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Abstract

An orally-taken quick-releasing Sitafuding in the form of oral disintegrating tablet, dispersing tablet, or oral dissolving tablet for preventing and treating AIDS is proportionally prepared from Sitafuding and medicinal auxiliary.

Description

Technical field: [0001] The invention relates to a stavudine oral immediate-release oral preparation for treating AIDS, which can rapidly disintegrate, release and mask bad taste, and a preparation method thereof, including orally disintegrating tablets, dispersible tablets and orally dissolving tablets. Background technique: [0002] Tablet is one of the most widely used oral solid dosage forms at present, and it has the advantages of convenient administration, storage and transportation, and drug stability. However, the full absorption of the drug is often affected by the slow disintegration and dissolution of the drug; at the same time, when the dose is large and more drugs need to be taken at one time, it often brings troubles to the elderly, children and patients with dysphagia. In this case, oral solutions, suspensions and emulsions are superior, but liquid preparations have disadvantages such as poor drug stability and inconvenient storage and transportation. For thi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7072A61K9/20A61P31/18
Inventor 杨琰崔正罡杨清娟董国霞王秀云王淑娟
Owner 中科医药行业生产力促进中心有限公司
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