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Incense-fuming solid-state formulation for treating nasitis and reagent bottle equipped with same

An aromatherapy and preparation technology, which is applied in the field of aromatherapy solid phase preparations, can solve the problems of being unsuitable for carrying around, the aromatherapy reagent bottle cannot meet the design requirements at the same time, and the use is inconvenient, and achieves good compatibility, good stability, and avoids volatilization. Effect

Inactive Publication Date: 2008-12-31
XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0029] None of the existing aromatherapy reagent bottles that have been announced can meet the design requirements of our products as therapeutic preparations and aromatherapy preparations at the same time. It is inconvenient to use, cannot play two functions at the same time, or is not suitable for carrying

Method used

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  • Incense-fuming solid-state formulation for treating nasitis and reagent bottle equipped with same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Effects on allergic rhinitis guinea pigs

[0065] Preparation of guinea pig allergic rhinitis model Take 40 guinea pigs of 300-350 g, half male and half male, and divide them into 5 groups, with 8 animals in each group. Except for one group as normal control, the remaining four groups were treated with 24 cresyl diisocyanate ( TDL) nasal drop sensitization. That is, 10 μl of 10% TDL olive oil solution was dripped into the bilateral nostrils of guinea pigs (5 μl on each side) with a sampler, once a day for 7 consecutive days. The method and dose of olive oil dripping in the group were the same as those in the model group.

[0066] The model judgment is based on the occurrence of nasal itching, scratching, sneezing, and runny nose as the judgment indicators. From the first administration of TDL to the sensitizer, different degrees of nasal itching, scratching, and sneezing can be seen within 30 minutes, and runny nose can be seen after 3 days. With the prolongation of th...

Embodiment 2

[0073] Preparation of a kind of aromatherapy solid-phase preparation for treating rhinitis (1)

[0074] 200mg soybean lecithin, 750mg magnolia volatile oil, 100mg cholesterol, 0.2mg sodium cholate, 1mg collagen were dissolved in 20ml of 2:1 methanol / chloroform mixed solvent. Constant temperature at 38°C, evaporate under reduced pressure to form a lipid film, add 20ml of phosphate buffer to shake and dissolve, adjust the pH value to 5.5, add 10mg of stearic acid amine, 0.05mg of polysorbate 80, and obtain a multilocular liposome dispersion. Ultrasonic treatment at an ultrasonic temperature of 10°C and an ultrasonic frequency of 200 Hz in an ice-water bath for 20 minutes, filtering through a 0.15 μm microporous membrane to form a uniform monolayer liposome suspension, adding 8.5 mg of phosphatidylglycerol to the filtrate to prepare Liposome suspension coated with magnolia volatile oil. The average particle size of the liposomes encapsulating the drug carrier in the suspension w...

Embodiment 3

[0076] Preparation of an aromatherapy solid-phase preparation for treating rhinitis (2)

[0077] 200mg egg yolk lecithin, 330mg magnolia volatile oil, 66mg cholesterol, 2.5mg sodium deoxycholate, 10mg vitamin A acetate, dissolved in a mixed solvent of 30ml methanol. Constant temperature at 28°C, evaporate under reduced pressure to form a lipid film, add 20ml of phosphate buffer to shake and dissolve, adjust the pH value to 7.0, add 100mg of diacetyl phosphate, 0.1mg of methylparaben, and obtain a multilocular liposome dispersion . Sonicate in an ice-water bath for 10 minutes at an ultrasonic temperature of 1°C and an ultrasonic frequency of 600 Hz, filter through a 0.15 μm microporous membrane to form a uniform monolayer liposome suspension, add 4 mg of phosphatidic acid to the filtrate to prepare a coating Liposome suspension of magnolia volatile oil. The average particle size of liposomes encapsulating the drug carrier in the suspension was determined to be 73nm, and the e...

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Abstract

The invention relates to an aromatherapy solid-phase preparation for treating rhinitis, which can be transformed into a solid phase and a liquid phase, and also relates to a reagent bottle containing the aromatherapy solid-phase preparation for treating rhinitis. The present invention relates to an aromatherapy solid-phase preparation for treating rhinitis and a reagent bottle containing the solid-phase preparation, which have the following advantages: (1) fat-soluble; (2) outsourcing phospholipids as body components, compatible with the body (3) When used as a fumigant, the drug can be slowly leaked only by body temperature, and the double-layer cover controls the volatilization speed of the drug; (4) By changing the external temperature, the phospholipid can be used to control and slow the release of the drug (5) As a nasal drop, it has a large specific surface area, which increases its contact area with the nasal mucosa and relatively prolongs its contact time with the nasal mucosa; (6) The nasal drop is nanoscale; (7) ) has better flexibility and deformability; (8) has better stability, and it avoids the decline of the drug effect due to the volatilization of Magnolia magnolia volatile oil.

Description

technical field [0001] The invention relates to an aromatherapy solid-phase preparation, in particular to an aromatherapy solid-phase preparation for treating rhinitis and a reagent bottle containing the solid-phase preparation. Background technique [0002] Magnolia volatile oil, a traditional Chinese medicine, is one of the best therapeutic drugs for allergic rhinitis, and its treatment for allergic rhinitis is non-unitary. It is an essential oil extracted from magnolia flower buds. It is warm in nature, pungent in taste, slightly bitter, and has a fresh and fragrant smell. It has the unique fragrance of traditional Chinese medicine and can be used as a good aromatherapy preparation. The therapeutic effects of magnolia mainly include the following aspects: [0003] (1) Anti-inflammatory effect. It can act on acute and chronic inflammation through multiple links. [0004] (2) Anti-allergic effect. It has obvious inhibitory effect on allergic asthma. [0005] (3) Antiba...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/127A61K36/575A61P11/02A61K133/00
Inventor 吴敏王雪梅张雄
Owner XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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