Data acquisition system for nuclein and fluorescent dual module integral small animal molecules imaging

Abstract

The invention belongs to the field of application of near-infrared laser, nuclear irradiation, electron and image rebuild in systematic biology and medicine. It is characterized in that high-specificity nuclear species and fluorescent probe are implanted in live animal to realize double mark of muscle deep layer or internal organ tumor cell. The emission signal of nuclear species is checked by sensitive electron-multiplier phototube in array copulation position of scintillation crystal; feeble fluorescent signal generated by visible light or infrared agitation is checked by high quantum yield CCD camera. The two checking systems are orthogonally arranged in the same surface, the live nuclear species and fluorescent signal can be checked simultaneously through rotary image cavity, and double module three dimensional tomography image of small animal can be rebuilt with software algorism. The invention is characterized by multi-image forming modules, abundant information and simple operation.

Description

technical field [0001] The data acquisition system for molecular imaging of small animals with nuclide and fluorescence dual-mode integration belongs to the comprehensive technical field of laser, nuclear radiation, electron and image reconstruction in the application of systems biology and medicine. Background technique [0002] The invention belongs to one of molecular image application technologies. After medical imaging technology experienced structural imaging and functional imaging, since the 1990s, with the development of biological and genetic technology and the improvement of imaging technology, new molecular imaging technology has emerged. It can realize non-invasive, dynamic and real-time in vivo imaging of physiological or pathological processes inside organisms at the gene, cell and molecular levels, so as to provide insights into disease-related gene function localization, cell growth and mutation process mechanism, new drug development, tumor Treatment and ot...

AI Technical Summary

Problems solved by technology

Although this solution can realize dual-mode detection, this system can only realize the self-luminescence measurement of animals, without the function of fluorescence imaging

Moreover, it is only planar imaging, and cannot perform tomographic imaging of small animals as a whole

In addition, this system requires a special photomultiplier tube, which is expensive, and the coupling between the crystal and the photomultiplier tube is also difficult, and the electronic system required for the separation of the two signals is also quite complicated.

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