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Test strip for detection of analyte and methods of use

A technology of test strips and reagents, applied in biological testing, biochemical equipment and methods, microbiological determination/inspection, etc., can solve the problems of test strip tray contamination, large sample volume, etc.

Inactive Publication Date: 2009-08-19
ACON BIOTECH (HANGZHOU) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these devices have many disadvantages
Some require large sample volumes to be applied to test strips, some have wetting issues, and some cause contamination of test strip trays

Method used

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  • Test strip for detection of analyte and methods of use
  • Test strip for detection of analyte and methods of use
  • Test strip for detection of analyte and methods of use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0089] Demonstrating the reduced wet-through problem of the test strips of the present invention

[0090]The following examples illustrate the ability of the test strip 10 of the present invention to reduce wet-through problems associated with other test strip 10 configurations.

[0091] The diaphragm 13 in each of the structures below was prepared in the same manner. Glucose oxidase / horseradish peroxidase system (Toyobo Inc., Tokyo, Japan) and AAP (4-aminoantipyrine, Sigma, St.Louis, MO) / MAOS (N-ethyl-N- (2-Hydroxy-3-sulfopropyl)-3,5-dimethylaniline, sodium salt, monohydrate, Dojindo Laboratories, Dumamoto, Japan) dye system impregnated membrane 13, Biodyne A with a pore size of 0.65 μm Nylon diaphragm 13 (Pall Corp., Port Washington, NY).

[0092] Structure A is an aspect of the invention. Structure A comprises a diaphragm 13 , which is secured to a top support layer 11 and positioned above a bottom support layer 15 , allowing the reflectometer to measure light scatter th...

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PUM

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Abstract

One aspect of the present invention is a reagent test strip that includes: a) a top support layer including a sample aperture; b) a membrane that includes a reagent system for indicating the concentration of a target; c) a spreading layer; d) a bottom support layer including a measuring port in substantial alignment or approximate alignment with the sample aperture. Preferably, the membrane is affixed to the top support layer. Preferably, the membrane is positioned between the top support layer and the bottom support layer. Preferably, the spreading layer is positioned above the top support layer and in substantial or approximate alignment with the sample aperture. Preferably, a fluid applied to the spreading layer, passes through the sample aperture and contacts the membrane.

Description

technical field [0001] The present invention generally relates to the field of test strip devices and methods of detecting analytes. More specifically, the present invention relates to test strips and methods of use for the colorimetric detection of glucose in whole blood. Background technique [0002] A wide variety of test strips for detecting analytes in test samples are available and described in the literature. Of these test strips, there are many that are used to detect glucose in whole blood. However, these devices suffer from a number of disadvantages. Some require large sample volumes to be applied to the test strips, some have wetting problems, and some cause contamination of the test strip tray. The present invention addresses these problems and provides related benefits. Description of drawings [0003] Figure 1a with Figure 1b is a perspective side view of a preferred embodiment of a test strip of the present invention. [0004] figure 2 is a side vi...

Claims

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Application Information

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IPC IPC(8): C12Q1/00C12Q1/54C12Q1/28G01N33/53G01N33/52
CPCC12Q1/54Y10S435/968Y10S435/97G01N33/525
Inventor J-N·林C-L·王
Owner ACON BIOTECH (HANGZHOU) CO LTD