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Cement ingredient, bone substitute material and method for forming cement ingredient

A technology of bone substitutes and cements, applied in surgical adhesives, medical science, surgery, etc., can solve problems such as difficult-to-adapt bone defects, achieve excellent resorption properties, improve processability, and improve radiopaque performance Effect

Inactive Publication Date: 2009-09-16
KYPHON
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, such ceramics have fixed dimensions, making it difficult to accommodate often irregularly shaped bone defects
It also has a disadvantage: calcium phosphate ceramics cannot be fully resorbed into tissues

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] A cement powder composition with the following components is provided, then, mixed with 3.5M (NH 4 ) 2 HPO 4 Aqueous solutions (liquid components) are mixed well to form a paste, which is then allowed to harden:

[0037] 65g TCP (tricalcium phosphate)

[0038] 12g Mg 3 (PO 4 ) 2

[0039] 4g MgHPO 4

[0040] 3g SrCO 3

[0041] 2g BaSO 4

[0042] The radiopacity of the resulting hardened calcium phosphate cement was evaluated visually on X-ray film. Obtain qualified X-ray contrast that can be clearly identified.

Embodiment 2

[0044] Repeat Example 1, the difference is to improve BaSO 4 amount to 8g, as follows:

[0045] 65g TCP (tricalcium phosphate)

[0046] 12g Mg 3 (PO 4 ) 2

[0047] 4g MgHPO 4

[0048] 3g SrCO 3

[0049] 8g BaSO 4

[0050] Since BaSO 4 Increased dosages yield improved radiopaque properties. The strength of the hardened cement was measured after a 2-hour incubation period at 37° C. in 0.9% by weight aqueous NaCl solution. The measured strength was 24.11MPa.

Embodiment 3

[0052] Example 1 was repeated except that instead of the radiopaque reinforcing agent, iocolic acid, an ionic organic iodine compound, was purchased from Guerbet GmbH (Sulzbach-Taunus, Germany):

[0053] 65g TCP (tricalcium phosphate)

[0054] 12g Mg 3 (PO 4 ) 2

[0055] 4g MgHPO 4

[0056] 3g SrCO 3

[0057] 2g iodic acid

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Abstract

The present invention relates to a bone cement comprising a powdered component comprising calcium phosphate and an aqueous liquid component. A radiopaque material is added to at least one of the powdered and liquid components, which can be combined into a paste that is applied to the bone.

Description

technical field [0001] The present invention relates to a formulation of a cement preparation for a bone substitute, which contains calcium phosphate as the main component and which is mixed with water or an aqueous liquid to obtain a paste or paste. The invention also relates to a process for the preparation of phosphate cements, especially apatite and struvite cements, from these formulations. Background technique [0002] Calcium phosphate ceramics have been on the market since 1970 as synthetic bone implants. However, such ceramics have fixed dimensions, making it difficult to accommodate bone defects, which are often irregular in shape. It also has the disadvantage that calcium phosphate ceramics cannot be adequately resorbed into tissues. Such poor resorbability comes from the sintering method of preparation, which forms a very dense structure. [0003] Since the 1980s, the advent of calcium phosphate cements represents a significant advance over existing bone ceram...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/00A61L24/02
CPCA61L2430/02A61L24/02
Inventor R·温斯
Owner KYPHON