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Radix Isatidis effervescence tablet and preparation method thereof

A technology of Radix isatidis and effervescent tablets, applied in the direction of medical formulas, medical preparations containing active ingredients, and medical raw materials derived from angiosperms, can solve problems such as large dosage, incomplete dissolution, and slow effect

Active Publication Date: 2009-10-21
JIANGZHONG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The original dosage forms have some shortcomings. In order to maintain the clarity of the oral liquid, a lot of active ingredients are lost during the alcohol precipitation process, which seriously affects the curative effect.
Capsules are generally not suitable for children and the elderly due to the inconvenience of swallowing; the disadvantages of ordinary tablets are solid dosage form absorption, slow effect, and low bioavailability; the disadvantages of tea and granules are that they need to be mixed with boiling water, and the dissolution is often incomplete , easy to produce precipitation, large dosage
The disadvantages of injections are high quality control requirements, difficult to control clarity and high cost, etc.

Method used

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  • Radix Isatidis effervescence tablet and preparation method thereof
  • Radix Isatidis effervescence tablet and preparation method thereof
  • Radix Isatidis effervescence tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] 1. Preparation of Radix Radix Radix Extract Powder

[0037] Take 5000g of Radix Radix and crush it into a coarse powder. After microwave treatment, add 10 times the amount of water to decoct twice, the first time for 2 hours, the second time for 1 hour, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.05-1.18 (measured at 80°C), washed with 60% ethanol until the pH value is 6-8, refrigerated, filtered, and the obtained filtrate recovers ethanol until it has no alcohol smell, sprays and dries to obtain the required extract powder. A total of 605 g of isatidis extract powder was obtained, with a yield of 12.1%.

[0038] 2. Prepare Isatidis effervescent tablets (100 tablets)

[0039] Formula ratio:

[0040] Banlangen Extract Powder 50g Citric Acid 60g

[0041] Stevia 2g Flavor 1g

[0042] Sodium bicarbonate 50g Sodium carbonate 10g

[0043] Low-substituted hydroxypropyl cellulose 14g PEG 6000 13g

[0044] 3. Preparation method

...

Embodiment 2

[0048] 1. The preparation of Radix Radix Radix Radix Extract powder is the same as in Example 1.

[0049] 2. Prepare Radix Radix effervescent tablet (100 pieces)

[0050] Formula ratio:

[0051] Banlangen Extract Powder 50g Tartaric Acid 70g

[0052] Cyclamate 2g Flavor 1g

[0053] Potassium bicarbonate 50g PEG 4000 16g

[0054] Microcrystalline Cellulose 10g PVP 1g

[0055] 3. Preparation method

[0056] The isatidis extract powder obtained by spray drying is sealed and stored for later use; tartaric acid, sodium bicarbonate, and microcrystalline cellulose are respectively crushed through a 100-mesh sieve, and sealed and stored for later use; cyclamate and essence are crushed through a 100-mesh sieve, and PEG 4000 is crushed through a 200-mesh sieve Sieve; during the preparation process, control the environmental temperature of the formulation at 25°C and the humidity below 45%; mix the Radix Radix Radix extract powder with tartaric acid according to the required proport...

Embodiment 3

[0059] 1. The preparation of Radix Radix Radix Radix Extract powder is the same as in Example 1.

[0060] 2. Prepare Radix Radix effervescent tablet (100 pieces)

[0061] Formula ratio:

[0062] Banlangen Extract Powder 50g Malic Acid 70g

[0063] Acesulfame K 3g Fragrance 1g

[0064] Sodium bicarbonate 50g Potassium carbonate 10g

[0065] Cross-linked polyvinylpyrrolidone 10g Magnesium stearate 6g

[0066] 3. Preparation method

[0067] The isatidis extract powder obtained by spray drying is sealed and stored for later use; malic acid, sodium bicarbonate, potassium carbonate, and cross-linked polyvinylpyrrolidone are respectively pulverized through a 100-mesh sieve; sealed and stored for later use; acesulfame potassium and essence are pulverized through a 100-mesh sieve , magnesium stearate was pulverized through a 140-mesh sieve; during the preparation process, the environmental temperature of the preparation was controlled at 25°C and the humidity below 45%; the Radix ...

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Abstract

The invention relates to an isatic root effervescence tablet and preparation process, wherein the medicament is prepared from radix isatidis as raw material through specific processes. The tablet has the effects of antibiosis, antiphlogistis, antiendotoxin, antiviruses and enhancing body immunity. The invention also as the advantages of improved biological availability, easy oral administration, small amount of dosage, and easiness in carrying. The selected auxiliary material and ring-shaped effervescent tablet can make the radix isatidis effervescent tablet disintegrate rapidly.

Description

technical field [0001] The invention relates to the technical field of Chinese patent medicine effervescent tablets and a preparation method thereof, in particular to the isatidis effervescent tablet and a preparation method thereof. Background technique [0002] At present, the main effervescent tablets in my country are health care products, such as vitamin C effervescent tablets, and some effervescent tablets for external gynecological medicine, such as Jieeryin effervescent tablets, metronidazole vaginal effervescent tablets, etc., but oral Chinese medicine Less effervescent preparations. And Radix Radix is ​​made into the effervescent tablet of oral pure Chinese medicine preparation, has not been reported yet. In addition, annular tablets have been used in the food industry for a long time, but they are rarely used in the field of medicine, especially in the field of effervescent tablet preparation, which has not been reported yet. [0003] Traditional Chinese medicine...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/46A61K9/20A61K36/315A61K36/19A61P31/00A61P37/04A61K125/00
Inventor 钟虹光罗晓健吕爱平周焘张国松曾志斌饶小勇
Owner JIANGZHONG PHARMA