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CCR ligands for stem cell homing

一种干细胞、CCR-2的技术，应用在动物细胞、脊椎动物细胞、细胞培养活性剂等方向

Inactive Publication Date: 2007-07-18
THE CLEVELAND CLINIC FOUND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This process does not occur at a rate sufficient for substantial recovery of left ventricular function after myocardial infarction

Method used

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  • CCR ligands for stem cell homing
  • CCR ligands for stem cell homing
  • CCR ligands for stem cell homing

Examples

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Embodiment Construction

[0112] The following series of examples further illustrate the invention. The following examples are offered for purposes of illustration but are not to be construed as limiting the scope or content of the invention in any way.

[0113] overview

[0114] MSCs can differentiate into a variety of organ-specific cell types, as well as regulate the local microenvironment of injured tissues and modulate the immune system. Little is known about how stem cells migrate / homing to injured tissue. Recently, a subpopulation of MSCs was shown to express the SDF-1 chemokine receptor CXCR4, and several studies suggest that this subpopulation may thus home in response to SDF-1. Interestingly, MSCs express SDF-1 themselves, but there is little precedent in the literature for cells migrating in response to their own secreted chemokines.

[0115] We have demonstrated that hematopoietic stem cells temporarily home to the heart after myocardial infarction. The temporality of HSC homing is du...

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Abstract

Chemokines ligands to at least one of CCR1, CCR2, CCR3, or CCR5 can be used to home stem cells for therapeutic applications.

Description

[0001] related application [0002] This application claims the benefit of US Provisional Application No. 60 / 581,571, filed June 21, 2004, which is hereby incorporated by reference. field of invention [0003] The present invention relates to chemokines, in particular to the use of chemokines for inducing chemotaxis of stem cells. Background of the invention [0004] Acute myocardial infarction (MI) remains the leading cause of morbidity and mortality in Western societies. Recent therapeutic advances have generally focused on restoring anterograde perfusion in the infarct-related artery, but there has been shown to be a "ceiling" in its effectiveness. Topol, E. J. Lancet 357, 1905-1914 (2001). A large proportion of patients with acute myocardial infarction (MI) eventually develop congestive heart failure (CHF), mainly due to left ventricular (LV) remodeling, a process that includes myocardial thinning, dilation, functional decline and ultimately death. Robbins, M.A. & O'...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/19A61K35/34C12N5/06A61K35/28C12N5/0775
CPCC12N2501/21C12N2502/1323A61K35/28A61K38/195C12N5/0663A61P43/00A61P9/10A61K2300/00
Inventor 马克·S·佩恩马修·凯德罗夫斯基
Owner THE CLEVELAND CLINIC FOUND
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