Method for multiple sclerosis treatment and prophylaxis by therapy leptospira infecion

A technology for multiple sclerosis and leptospirosis, applied in allergic diseases, antibody medical ingredients, pharmaceutical formulations, etc., can solve the problem of no pathogen, no disease-specific treatment or diagnosis, etc.
CN101010098AInactive Publication Date: 2007-08-01UNIVERSITY OF COPENHAGEN

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
UNIVERSITY OF COPENHAGEN
Publication Date
2007-08-01
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention provides novel therapies and novel prophylactic methods for multiple sclerosis. Also provided are novel diagnostic methods. The invention resides in the finding that multiple sclerosis most likely is caused by chronic infection with a microorganism that cross-reacts immunologically with the spirochete Leptospira interrogans, which normally infects the brown rat.
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Description

field of invention

[0001] The present invention relates to the fields of treatment, prevention, diagnosis and monitoring of multiple sclerosis (MS). In particular, the present invention proposes to treat and prevent MS by targeting pathogenic factors associated with Rattus norvegicus. In this context, the present invention provides a human therapy by targeting the spirochetes Leptospira, in particular L. interrogans, which endemicly infect rats. Background of the invention

[0002] Current knowledge about multiple sclerosis

[0003] The following background notes on MS are largely taken directly from the Multiple Sclerosis International Federation homepage www.msif.org .. When including other sources of information, provide references.

[0004] Multiple sclerosis is a particularly difficult disease to study for a number of reasons:

[0005] • The etiology is unknown, although it is generally believed to be a combination of genetic, immune, and environmental factors. ...

Claims

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