Medicine for treating chronic renal failure and its preparing process

Abstract

This invention relates to a medicine for chronic renal failure and its preparation method, and belongs to the technology field of preparing medicine for treating chronic renal failure. The medicine is characterized in comprising the active constituent of F-Glycocalyx which is the valid target of ecklonia kurome and is protein polysaccharides containing sulfate group extracted from ecklonia kurome. the preparation method of F-Glycocalyx comprise (1) selecting, (2) soaking and cleaning, (3) pulverizing, (4) extracting with water, (5) precipitating with alcohol of low concentration, (6)precipitating with alcohol of high concentration, and (7) purifying to obtain purified product, drying, and packaging. The inventive medicine can effectively inhibit malignant tumor viral, improve immunity with no toxicity and adverse side effect, no untoward reaction and low cost.

Description

1. Technical field

[0001] The invention relates to a medicine for treating chronic renal failure and a preparation method thereof, belonging to the technical field of medicine for treating renal failure. 2. Background technology

[0002] Chronic renal failure is a common clinical disease. At present, the treatment effect is obviously unsatisfactory, and there is still no curable drug in the world. Most of the drugs currently used for treatment are chemical drugs. Although they can relieve symptoms and prolong the course of the disease, there are still many problems: the virus in the body cannot be completely removed, and the drug is discontinued. Rebound, easy to produce drug resistance, large side effects and high treatment costs, so that the application of these drugs is greatly restricted, so low toxicity, effective and cheap traditional drugs, especially traditional Chinese medicine, have attracted much attention at home and abroad. 3. Contents of the invention [000...

Examples

Embodiment 1

[0027] A medicine for treating chronic renal failure, the active ingredient contained in it is F-glycoside peptide, F-glycoside peptide is the effective part of the single Chinese medicine kelp, and it is a sulfate group-containing compound extracted from the single traditional Chinese medicine kelp Its main physical and chemical characteristics are: easily soluble in water, solubility ≥ 30%, white or yellow polycrystalline powder, with special fragrance; SO 4 2- The content is 20±5%, the fucose content is 20±5%, and the protein content is 10-18%.

[0028] The preparation method of the medicine includes the following steps of producing and extracting the F-glycoside peptide: 100kg of seaweed is soaked, washed, crushed, added with 800kg of water, and extracted three times at 90-100°C for 3.5 hours. The supernatant was concentrated under reduced pressure to 25 L, precipitated under 30% ethanol, then the supernatant was evaporated to 10 L under reduced pressure, added to 85 L of...

Embodiment 2

[0030] (1) Clinical data and methods

[0031] 1. Inclusion criteria: age 18-70 years old, patients with stage I and II stage selected according to CRF diagnostic criteria as research objects.

[0032] 2. General information and grouping: 67 cases in this group, including 37 males and 30 females, aged 18-70 years, with a course of 6 months to 15 years, with an average of 4.1 years. The primary disease was chronic very glomerulonephritis 22 20 cases of diabetic nephropathy, 5 cases of hypertensive nephropathy, 6 cases of gouty nephropathy, 4 cases of Henoch-Schonlein purpura nephritis, 4 cases of lupus nephritis. Renal function stage I stage 28 cases, II stage 39 cases. 67 patients were randomly divided into two groups, 34 cases in the treatment group, 22 males and 12 females, with an average age of 35.03±12.0 years, and a disease course of 6-28 months, with an average of 11.2±9.6 months. There were 33 cases in the control group, 22 males and 11 females, with an average age of...

1. Technical field

[0001] The invention relates to a medicine for treating chronic renal failure and a preparation method thereof, belonging to the technical field of medicine for treating renal failure. 2. Background technology

[0002] Chronic renal failure is a common clinical disease. At present, the treatment effect is obviously unsatisfactory, and there is still no curable drug in the world. Most of the drugs currently used for treatment are chemical drugs. Although they can relieve symptoms and prolong the course of the disease, there are still many problems: the virus in the body cannot be completely removed, and the drug is discontinued. Rebound, easy to produce drug resistance, large side effects and high treatment costs, so that the application of these drugs is greatly restricted, so low toxicity, effective and cheap traditional drugs, especially traditional Chinese medicine, have attracted much attention at home and abroad. 3. Contents of the invention [000...

Examples

Embodiment 1

[0027] A medicine for treating chronic renal failure, the active ingredient contained in it is F-glycoside peptide, F-glycoside peptide is the effective part of the single Chinese medicine kelp, and it is a sulfate group-containing compound extracted from the single traditional Chinese medicine kelp Its main physical and chemical characteristics are: easily soluble in water, solubility ≥ 30%, white or yellow polycrystalline powder, with special fragrance; SO 4 2- The content is 20±5%, the fucose content is 20±5%, and the protein content is 10-18%.

[0028] The preparation method of the medicine includes the following steps of producing and extracting the F-glycoside peptide: 100kg of seaweed is soaked, washed, crushed, added with 800kg of water, and extracted three times at 90-100°C for 3.5 hours. The supernatant was concentrated under reduced pressure to 25 L, precipitated under 30% ethanol, then the supernatant was evaporated to 10 L under reduced pressure, added to 85 L of...

Embodiment 2

[0030] (1) Clinical data and methods

[0031] 1. Inclusion criteria: age 18-70 years old, patients with stage I and II stage selected according to CRF diagnostic criteria as research objects.

[0032] 2. General information and grouping: 67 cases in this group, including 37 males and 30 females, aged 18-70 years, with a course of 6 months to 15 years, with an average of 4.1 years. The primary disease was chronic very glomerulonephritis 22 20 cases of diabetic nephropathy, 5 cases of hypertensive nephropathy, 6 cases of gouty nephropathy, 4 cases of Henoch-Schonlein purpura nephritis, 4 cases of lupus nephritis. Renal function stage I stage 28 cases, II stage 39 cases. 67 patients were randomly divided into two groups, 34 cases in the treatment group, 22 males and 12 females, with an average age of 35.03±12.0 years, and a disease course of 6-28 months, with an average of 11.2±9.6 months. There were 33 cases in the control group, 22 males and 11 females, with an average age of...