Concatenate antigen membrane detecting kit and its preparing method

A detection kit and antigen technology are applied in the field of rheumatoid arthritis multi-antigen patch method detection kits, which can solve the problems of insufficient detection sensitivity and specificity, cumbersome operation, etc. Simple operation, strong practical effect

Inactive Publication Date: 2007-08-29
SHANGHAI KEXIN BIOTECH
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Problems solved by technology

[0005] Aiming at the above-mentioned deficiencies in the prior art, the inventors of this case designed and prepared the multi-antigen immunoblotting membrane method, using one patient serum and one detection reaction to detect multiple RA

Method used

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  • Concatenate antigen membrane detecting kit and its preparing method
  • Concatenate antigen membrane detecting kit and its preparing method
  • Concatenate antigen membrane detecting kit and its preparing method

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Example Embodiment

[0035] The present invention will be further described in detail below with reference to the drawings and embodiments.

[0036] As shown in Figures 1-3, a preferred embodiment of the present invention provides a multi-linked antigen patch method detection kit capable of diagnosing RA, which includes a slide, a reaction tank and supporting liquid reagents.

[0037] As shown in FIG. 1, the slide is supported by glass or plastic, and the notch 101 on the upper right of the slide corresponds to the notch 201 on the upper right of the reaction tank, which plays a role in positioning. There are 2-6 individual reaction areas 102 on the slide, corresponding to the 2-6 grooves 202 in the reaction tank. Each reaction area is affixed with 2 film strip test papers 103, and each film strip test paper is printed with RA The antigen and reaction quality control band.

[0038] The RA-related antigens on the slide mainly refer to more than four antigens among RF, anti-CCP, anti-RA-33 antibody, ant...

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Abstract

The invention relates to a test reagent box of multiple antigen membrane method which is used for diagnosing RA, it includes tablets and response groove, the tablets hold on the response groove; the tablets gap corresponding to the response groove gap; there is multi-personal reaction zone on the tablets which correspond with the multi-groove of reaction groove, there is a gap on the top of each groove; membrane bar test paper adhere to each reaction zone and with RA correlate antigen and response control belt; the RA related antigen is the corresponding antigen of RF, anti-CCP, anti-RA-33 antibody, anti-Sa antibody, anti-P68 or more than four kinds of antigen in antigen epitope polypeptide or antigen epitope polypeptide, the response control belt is a mixture of man IgG and man IgM. The reagent box in this invention overcome the lack of detection sensitivity and Specificity of the single autoantibody and the red tape of several autoantibody detection in a single operation, it provide the accuracy and convenience of RA diagnosis. The invention also disclosed the method of how to make the test box.

Description

technical field [0001] The present invention relates to a rheumatoid arthritis (RA) multi-antigen patch method detection kit and a preparation process thereof, more specifically relates to making a plurality of antigens related to rheumatoid arthritis on the detection kit, It is used to detect whether there are autoantibodies related to rheumatoid arthritis in human serum. Background technique [0002] Rheumatoid arthritis (hereinafter referred to as RA) is the most common systemic autoimmune disease mainly characterized by chronic polyarticular inflammation. The sickness rate of this disease in my country is about 0.36%, and the patient age of onset is mostly in 20-50 years old, and the female is more than the male, and the ratio of male to female is 1: 3. Its prominent early clinical manifestations are symmetrical polyarticular redness, swelling, heat pain, small joints of extremities, proximal interphalangeal joints swelling, metacarpophalangeal (plantar toe), wrist, elb...

Claims

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Application Information

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IPC IPC(8): G01N33/558G01N33/544
Inventor 杨子义倪健魏国兰丁妍陈闻卓
Owner SHANGHAI KEXIN BIOTECH
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