Nanometer fluorouracil coat artificial crystalloid and the preparing method

A fluorouracil and intraocular lens technology, applied in the field of medicine, can solve the problems of obstructing the passage of light, appearing opacity and shrinking, affecting the improvement of vision, etc., and achieves the effect of inhibiting the opacity of the capsule, having low intraocular toxicity, and preventing the subsequent cataract.
CN101036804AInactive Publication Date: 2007-09-19SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Publication Date
2007-09-19
Estimated Expiration
Not applicable Β· inactive patent
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Abstract

The invention relates to a intraocular lens. At present the Poly-Methyl Methacrylate (PMMA) intraocular lens conventional for clinical treatment of cataract always causes inflammatory treaction after implantation. Posterior capsule opacification is also a major compalication after cataract surgery. The invention selects fluorouracil to solve the above problems. Based on weak penetrating force of chitosan nanoparticles in eyes and the relation between the phagocytosis amount of conjunctival epithelial cells to nanoparticles and the particle size of nanoparticles, the fluorouracil nanoparticles preparation is prepared using chitosan-poly(acrylic acid) as carrier, composite coated on the surface of PMMA intraocular lens. The invantion also provides a preparation method thereof. The said intraocular lens not only increases the biocompatibility of the intraocular lens, but also inhibites posterior capsule opacification pafter cataract surgery. The said intraocular lens can also prevent anterior membrane after implantation of intraocular lens and after-cataract.
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Description

Technical field:

[0001] The invention relates to the technical field of medicine, in particular to a coated intraocular lens (intraocular lens, IOL) and a preparation method thereof. Background technique:

[0002] Fluorouracil (Fluorouracil, 5-Fu) is an inhibitor of thymidylate synthase, which can effectively inhibit cell mitosis and is a commonly used antineoplastic drug in clinic. Studies have found that fluorouracil can inhibit the proliferation and migration of lens epithelial cells (see Sun Yanxiu, Li Xiaorong, Zhang Xiaohong, etc., 5-fluorouracil inhibits rabbit lens epithelial cells (lens epithelial cells, LECs) proliferation and intraocular toxicity research, Ophthalmology Research, 2000 ; 18(3):224-226), which can be used to prevent intraocular lens anterior membrane and posterior cataract after intraocular lens implantation, and can also prevent scar formation after glaucoma surgery (see Xiong Xiaoling, 5-Fu anti-scar after glaucoma surgery Formation of experiment...

Claims

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