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Health-care product for reducing weight and lowering cholesterin content in blood

A technology for lowering cholesterol and health care products, applied in the field of health care products, can solve the problems of indigestion, large dosage, difficulty in long-term medication, etc., and achieve the effects of promoting peristalsis and simple preparation method.

Active Publication Date: 2007-10-03
张涉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, they all have a strong foul smell, and taking large doses can easily cause gastrointestinal reactions such as nausea, abdominal pain, and indigestion, and bring many difficulties to long-term medication.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] The list of raw materials adopted in the embodiment and the foregoing process is as follows:

[0064] No Raw material and reagent name Source

[0065] 1 Konjac Glucomannan Chengdu Paite Biotechnology Co., Ltd.

[0066] 2 Fmoc-Arg(Pbf)-OH Gill Biochemical (Shanghai) Co., Ltd.

[0067] 3 Fmoc-Lys(Boc)-OH Gill Biochemical (Shanghai) Co., Ltd.

[0068] 4 HOBt Jill Biochemical (Shanghai) Co., Ltd.

[0069] 5 DCC Sinopharm Chemical Reagent Co., Ltd.

[0070] 6 Trifluoroacetic acid (TFA) Sinopharm Chemical Reagent Co., Ltd.

[0071] 7 MeOH Sinopharm Chemical Reagent Co., Ltd.

[0072] 8 Dichloromethane Sinopharm Chemical Reagent Co., Ltd.

[0073] 9 Dimethylformamide (DMF) Sinopharm Chemical Reagent Co., Ltd.

[0074] 10 Ethanol Sinopharm Chemical Reagent Co., Ltd.

[0075] 11 Hexahydropiperidine (PIP) Sinopharm Chemical Reagent Co., Ltd.

[0076] 12 DMAP Sinopharm Chemical Reagent Co., Ltd.

[0077] In the example:

[0078] Said decapping reagent is: PIP:DMF=1:3, v...

Embodiment 2

[0094] Synthetic polyamino acid glucomannan:

[0095] (1) Preparation of Fmoc-Arg(Pbf)-glucomannan

[0096] Weigh 8 grams of glucomannan, swell with 50ml DMF for 30 minutes to fully swell the glucomannan, add 2ml DMAP, 0.02g HOBt, 0.03g DCC, 0.10g Fmoc-Arg(Pbf)-OH, and react at 50°C for 1.5 hours , blow dry. Methanol, CH 2 Cl 2 and DMF were washed three times respectively, and dried to obtain Fmoc-Arg(Pbf)-glucomannan.

[0097] (2) Preparation of Fmoc-Arg(Pbf)-Arg(Pbf)-glucomannan

[0098] In the Fmoc-Arg(Pbf)-glucomannan in step (1), add the decapping reagent, react at 35°C for 40 minutes, blow dry, and use MeOH, CH 2 Cl 2 , DMF each washed three times, and dried. Add 0.02g HOBt, 0.03g DCC, 0.10g Fmoc-Arg(Pbf)-OH, react at 50°C for 1.5 hours, and blow dry. Respectively with MeOH, CH 2 Cl 2 , washed three times with DMF, and dried to obtain Fmoc-Arg(Pbf)-Arg(Pbf)-glucomannan.

[0099] (3) Preparation of Fmoc-Arg(Pbf)-Arg(Pbf)-Arg(Pbf)-glucomannan

[0100] In the Fm...

Embodiment 3

[0108] Synthetic polyamino acid glucomannan:

[0109] (1) Preparation of Fmoc-Arg(Pbf)-glucomannan

[0110] Weigh 5 grams of glucomannan, swell with 25ml DMF for 30 minutes to fully swell the glucomannan, add 1ml DMAP, 0.02g HOBt, 0.03g DCC, 0.10g Fmoc-Arg(Pbf)-OH, and react at 10°C for 4 hours , blow dry. Add methanol, CH 2 Cl 2 and DMF were washed three times, and dried with nitrogen to obtain Fmoc-Arg(Pbf)-glucomannan.

[0111] (2) Preparation of Fmoc-Arg(Pbf)-Arg(Pbf)-glucomannan

[0112] Add a decapping reagent to the Fmoc-Arg(Pbf)-glucomannan in step (1), react at 10° C. for 70 minutes, and blow dry. With MeOH, CH 2 Cl 2 , DMF each washed three times, and dried. Add 0.03g HOBt, 0.04g DCC, 0.13g Fmoc-Arg(Pbf)-OH, react at 25°C for 2 hours, blow dry, wash with MeOH, CH 2 Cl 2 , washed three times with DMF, and dried to obtain Fmoc-Arg(Pbf)-Arg(Pbf)-glucomannan.

[0113] (3) Preparation of Fmoc-Arg(Pbf)-Arg(Pbf)-Arg(Pbf)-glucomannan

[0114] To the Fmoc-Arg(Pbf)...

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PUM

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Abstract

A health-care food for reducing weight and decreasing cholesterol is prepared from the refined conjak starch through purifying to obtain high-purity glucomannan, and linking a certain number of polyarginines or polylysines to its hydroxy group.

Description

Technical field: [0001] The invention relates to a health product, in particular to a health product for weight loss and cholesterol reduction. Background technique: [0002] Cardiovascular and cerebrovascular diseases are the number one killer threatening the health and lives of people around the world. In China, about 2.6 million people die from cardiovascular and cerebrovascular diseases every year, about 7,000 people die from cardiovascular and cerebrovascular diseases every day, and one person dies from cardiovascular and cerebrovascular diseases every twelve seconds. The most important risk factors for cardiovascular and cerebrovascular diseases are high blood pressure, high cholesterol, diabetes, obesity and smoking. With the development of the economy and the improvement of living standards, great changes have taken place in the lifestyle and diet structure of the Chinese population. People's diet has changed from food and vegetables in the 1950s and 1960s to a hig...

Claims

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Application Information

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IPC IPC(8): A23L1/29A23L1/305A23L1/307A23L1/28A23L1/214A61K31/195A61K31/716A61P3/02A61P3/04A61P3/06A61P9/00A23L33/175
Inventor 张涉马辉文刘成文
Owner 张涉
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