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Corydalis total alkali clathrate, its preparing method and application

A technology without total alkalis and inclusion compounds in summer. It is applied in the directions of inactive components of polymer compounds, drug combinations, and pharmaceutical formulations. It can solve the problems of low encapsulation efficiency and drug loading, low total alkali content, and low solubility. , to achieve the effect of reducing the encapsulation rate and drug loading, low yield loss and improving quality

Inactive Publication Date: 2008-04-16
SHANGHAI INST OF PHARMA IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] Therefore, the technical problem to be solved by the present invention is to overcome the low solubility in summer without total alkali water, the low content of total alkali in the summer without total alkali inclusion compound in the prior art, and the shortcomings of low encapsulation efficiency and drug loading capacity.

Method used

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  • Corydalis total alkali clathrate, its preparing method and application
  • Corydalis total alkali clathrate, its preparing method and application
  • Corydalis total alkali clathrate, its preparing method and application

Examples

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Effect test

Embodiment 1

[0036]Method: Weigh 4g x 5 parts of HP-β-CD (Xi'an Deli Biochemical Co., Ltd., batch number 20051202), add 25ml of absolute ethanol (No. The mass ratio of host and guest was shown by adding summer-free total alkali powder, stirring magnetically at room temperature for 2.5 hours, rotating and concentrating to dryness at 45°C, and drying under reduced pressure at 50°C to obtain a yellow solid powder.

[0037]

Embodiment 2

[0039] Method: Weigh 4g x 5 parts of HP-β-CD, add the corresponding volume of absolute ethanol to the concentration of HP-β-CD shown in the table below to dissolve, add 0.25g summer free total alkali powder each, and stir magnetically at room temperature After 2.5 hours, it was concentrated to dryness at 45°C by rotation, and dried under reduced pressure at 45°C to obtain a yellow solid powder.

[0040]

Embodiment 3

[0042] Method: Weigh 4g×4 parts of HP-β-CD, add 40ml of absolute ethanol to dissolve each, add 0.25g of summer free total alkali powder respectively, carry out magnetic stirring at room temperature for inclusion time as shown in the table below, and rotate and concentrate at 45°C to dryness, and dried under reduced pressure at 60°C to obtain a yellow solid powder.

[0043]

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Abstract

A rhizoma corydalis total alkaloids inclusion compound is disclosed in the present invention, the inclusion compound in the heat absorbing curve obtained by detecting with differential scanning calorimetry, in temperature 300 to 380 C DEG range has obvious heat absorbing peak, the temperature of the maximum heat absorbing peak of the heat absorbing peaks is 335 to 365 C DEG. Its preparation method is with hydroxyl-beta-cyclodextrin as subject, with rhizoma corydalis total alkaloids as object, under absolute ethanol existing by inclusion operation, to inclusion or embed the rhizoma corydalis total alkaloids into hydroxyl-beta-cyclodextrin, forming inclusion compound. Application of the rhizoma corydalis total alkaloids inclusion compound in preparing medicine preparations such as tablet, capsule, soft capsule, granule, oral rapidly disintegrable preparation, slow release preparation or freeze-dried injection powder and etc. The rhizoma corydalis total alkaloids inclusion compound of the present invention is very easy or easy to solute in water, promotes water solubility and stability, and stores conveniently.

Description

technical field [0001] The invention relates to a traditional Chinese medicine inclusion compound, in particular to a summer free total alkali inclusion compound, a preparation method and application thereof. Background technique [0002] Summer Wu is the dry tuber or whole herb of Corydalis decumbens (Thunb.) Pers., a plant of the genus Corydalis in the family Papaveraceae. Summer Wu is widely distributed in Jiangsu, Anhui, Zhejiang, Jiangxi, Fujian, Taiwan, Hunan and other provinces. Commonly used Chinese herbal medicine in my country has the effects of promoting blood circulation, dredging collaterals, promoting qi, and relieving pain. It is mainly used for the treatment of stroke and hemiplegia caused by high blood pressure and cerebrovascular disease, and has a good effect on rheumatoid arthritis, sciatica, and sequelae of polio. Its main active ingredients are total isoquinoline alkaloids, most of which are fat-soluble components. So far, more than 30 isoquinoline alka...

Claims

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Application Information

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IPC IPC(8): A61K36/66A61K47/40A61K9/16A61K9/19A61K9/20A61K9/48A61P9/12A61P9/10
Inventor 杨义芳蒋爱芳
Owner SHANGHAI INST OF PHARMA IND
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