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Alkyl-glycoside enhanced vaccination

A technology of alkyl glycosides and alkyls, which is applied in the field of inoculation enhanced by alkyl glycosides, and can solve problems such as limited use

Inactive Publication Date: 2008-04-16
UAB RES FOUND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, commonly used protein-based vaccines have been studied (Glenn et al., "Skin immunization made possible by cholera toxin" Nature 391:851, 1998); however, their usefulness is limited

Method used

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  • Alkyl-glycoside enhanced vaccination
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  • Alkyl-glycoside enhanced vaccination

Examples

Experimental program
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Embodiment

[0122] In order to provide those skilled in the art with a complete disclosure and description of how to make and evaluate the compounds, compositions and methods described and claimed herein, the following examples are presented and are intended to be illustrative only and not intended to to limit the scope of what the inventor believes to be the invention. With regard to numbers (eg, amounts, temperatures, etc.), efforts have been made to ensure accuracy but some errors and deviations should be accounted for. Unless indicated otherwise, parts are parts by weight, temperature is in °C or is at ambient temperature, and pressure is at or near atmospheric. There are various variations and combinations of reaction conditions, eg, ingredient concentrations, desired solvents, solvent mixtures, temperature, pressure, and other reaction ranges and conditions, that can be used to optimize the product purity and yield obtained from the process. All that is required is reasonable and r...

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Abstract

Described herein are methods for the noninvasive immunization of a subject that involve alkyl glycosides. Also described herein are compositions, kits, and devices for the noninvasive immunization of a subject.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to U.S. Provisional Application No. 60 / 655,318, filed February 23, 2005, which is hereby incorporated by reference in its entirety. Background of the invention [0003] Activation of the immune system of vertebrates is an important mechanism for protecting animals against pathogens and malignancies. The immune system is made up of many interrelated components, including humoral and cellular branches. Humoral immunity involves antibodies that directly bind antigens. Antibody molecules that are effectors of humoral immunity are secreted by B lymphocytes. Cellular immunity involves specialized cytotoxic T lymphocytes (CTLs) that recognize and kill other cells and produce non-self antigens. CTLs respond to degraded peptide fragments that appear on the surface of target cells that bind class I MHC (major histocompatibility complex) molecules. It is understood that as part of cellular metab...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/00A61K35/74A61K35/76A61K35/761A61K39/00
CPCA61K2039/55583A61K2039/55511A61K39/235A61K2039/5254A61K2039/54A61K47/26A61K9/0014A61K39/39A61K31/70C12N2710/10043A61K39/12A61P31/04A61P35/00Y02A50/30A61K48/00A61K39/00
Inventor J·J·阿诺黄俊铭E·米赞D·J·皮利恩唐代驹
Owner UAB RES FOUND