Self-emulsifying preparations for treating gastropathy and preparation method thereof

Abstract

The invention relates to self emulsifying preparation for treating gastrosis, in particular to the self emulsifying preparation with chenopodium oil or / and Adina pilulifera oil as the basis. The self emulsifying preparation comprises the basis, rape seed salad oil and surfactant, and can also comprise cosurfactant. The preparation of the invention improves the solubility of the chenopodium oil and the Adina pilulifera oil in solvent, enhances the stability, is manifested as the self emulsifying preparation, and enhances the bioavailability of the preparation through the double targeting absorption of mononucleophage and a lymphatic system.

Description

technical field [0001] The invention relates to a self-emulsifying preparation for treating stomach diseases, in particular to a self-emulsifying preparation with nepeta oil or / and Shuituanhua oil as main agents and a preparation method thereof. Background technique [0002] Jinghua Weikang Capsules use the volatile oil extracted from Nepeta chinensis and Shuituanhua as the main drug. Experimental studies have found that it is effective for stress ulcers, pyloric ligation ulcers, acetic acid burning gastric ulcers, reserpine, and indomethacin. , histamine and other drugs-induced gastric ulcers have good protective effects, and also have obvious inhibitory effects on gastrointestinal motility, which can antagonize Ach, BaCI 2 And histamine excitatory effect on intestinal tract, has antispasmodic effect on gastrointestinal smooth muscle, and can relieve pain caused by upper peptic ulcer. In the in vitro experimental study, Xie Zhenjia and Huang Meixing (Jinghua Weikang Capsul...

AI Technical Summary

Problems solved by technology

[0004] 1. Insufficient permeability: Nepeta oil and water group flower oil are both volatile oils. Since there is no emulsification system in the stomach, the permeability of fat-soluble components is relatively poor, resulting in incomplete pharmacological effects on the gastric mucosa;

[0005] 2. Insufficient absorption: Jinghua Weikang Capsules have good anti-HP effect in vitro. Experiments have proved that anti-HP drugs mainly exert systemic effects through intestinal absorption, while Nepeta oil and water group flower oil are absorbed through the gastrointestinal tract The effect is not ideal;

[0006] 3. Irritation: Nepeta oil and water group flower oil are quite irritating. While treating ulcers, it is very likely to induce gastric ulcers at the same time;

[0007] 4. Slow disintegration: Jinghua Weikang is a soft capsule preparation, and the disintegration degree of soft capsules is greatly affected by factors such as preparation process and storage conditions. It is very likely that it will not disintegrate in the stomach at all, and its pharmacological effects are great. Affected