Patch for treating angina

A technology of angina pectoris and patch, which is applied in the field of drugs for treating angina pectoris, which can solve the problems of toxic side effects and long treatment cycle, and achieve the effects of stable drug properties, fast transdermal absorption, and easy use and portability

Inactive Publication Date: 2008-06-18
TIANJIN ZHONGBAO PHARMACY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, oral preparations are mostly used in the treatment of angina pectoris, and no external preparations have been seen. Oral administration has a long treatment cycle and relatively large toxic and side effects.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1: the patch for the treatment of angina pectoris (trade name: angina pectoris patch)

[0034] prescription:

[0035] Red peony 120g Angelica 100g Salvia 150g Safflower 100g Peach kernel 100g Hawthorn 300g

[0036] Turmeric 150g, Jiangxiang 90g, Chuanxiong 120g;

[0037] Preparation:

[0038] A. Extraction process

[0039] (a) Take the nine herbs such as Radix Paeoniae Rubra, decoct twice with water, first use 8 times the amount of water, decoct for 2 hours, and use 6 times the amount of water for the second time, decoct for 2 hours, filter, and combine the filtrates , concentrated under reduced pressure to a relative density of 1.25, left to cool at room temperature, added ethanol to make the alcohol content 70%, stirred well, allowed to stand for 12 hours to precipitate, took the supernatant to recover ethanol, concentrated under reduced pressure to a relative density of 1.40 Thick paste, vacuum-dried at 65°C to obtain dry matter, crushed, and passed th...

Embodiment 2

[0044] Embodiment 2: the patch for treating angina pectoris (trade name: angina pectoris cataplasm)

[0045] prescription:

[0046] Red peony 120g Angelica 100g Salvia 150g Safflower 100g Peach kernel 100g Hawthorn 300g

[0047] Turmeric 150g, Jiangxiang 90g, Chuanxiong 120g;

[0048] Preparation:

[0049] A. Extraction process:

[0050] (a) Take the nine herbs such as Radix Paeoniae Rubra, decoct twice with water, first use 8 times the amount of water, decoct for 2 hours, and use 6 times the amount of water for the second time, decoct for 2 hours, filter, and combine the filtrates , concentrated under reduced pressure to a relative density of 1.25, left to cool at room temperature, added ethanol to make the alcohol content 70%, stirred well, allowed to stand for 12 hours to precipitate, took the supernatant to recover ethanol, concentrated under reduced pressure to a relative density of 1.40 Thick paste, vacuum-dried at 65°C to obtain dry matter, crushed, and passed throu...

Embodiment 3

[0056] Embodiment 3: the stability investigation of the patch ointment for the treatment of angina pectoris

[0057] According to the "Technical Requirements for New Drug Research of Traditional Chinese Medicine" promulgated and implemented by the State Drug Administration, the technical requirements for quality stability research of new traditional Chinese medicines are stipulated. The ointment and cataplasm for treating angina pectoris were made according to the established process, and the properties, moisture retention, content and microbiological inspection items were observed at room temperature. The results show that all the control indicators meet the national ointment quality standards, and the quality is stable after being placed at room temperature for six months.

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Abstract

The invention discloses a plaster for treating angina. The effective ingredients contain Radix Paeoniae Rubra, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Flos Carthami, Semen Persicae, Fructus Crataegi Pinnatifidae, Radix Curcumae Aromaticae, Lignum Dalbergiae Odoriferae and Rhizoma Chuanxiong. The invention is a compound externally used paste refined in the aqueous extraction-alcohol precipitation technology , has the efficacies of activating blood and dredging meridians and collaterals, dispersing blood stasis and relieving pain and has evident effect on angina. The paste of the plaster is easy to be coated on a piece of cloth and not easy to be melted because of the fine, soft and smooth quality; the paste is also easy for use and carrying because of small size and can promote the focus to quickly recover. The poultice has stable drug property and has the characteristics of quick percutaneous absorption, good ventilation property and gradual drug releasing. Compared with the oral preparation, the invention has the advantages of no liver-intestines first-filter action, no influence from gastrointestinal degradation and high bioavailability. Compared with injection, the invention has the advantages of convenient use and no pain. Compared with ointment, the invention has the advantages of accurate dose and fixed absorption area. Compared with black plaster and sticking plaster, the invention has the advantages of no sensibility on skin, no pollution to clothes, long effect, percutaneous absorption and convenient carrying and use.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, in particular to a medicine for treating angina pectoris. Background technique [0002] Xuefu Zhuyu Capsule is a classic Chinese patent medicine, the Ministry of Health standard WS 2 -B-0928-91 records the prescription: [0003] Peach kernel (fried) 200g Angelica 150g Citrus aurantium (bran fried) 100g Chuanxiong 75g Bupleurum 50g [0004] Safflower 150g Achyranthes bidentata 150g Radix Paeoniae Rubra 100g Rehmannia glutinosa 150g Bellflower 75g Licorice 50g [0005] Functions and indications: promoting blood circulation and removing blood stasis, promoting qi and relieving pain. Used for blood stasis internal resistance, chest pain or headache, internal heat and depression, insomnia and dreaminess, palpitations, irritability and anger. [0006] Preparation Process: [0007] Grind 100g of peach kernels, angelica, red peony root, citrus aurantii, Chuanxiong, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K9/06A61K9/70A61P9/10
Inventor 李建民
Owner TIANJIN ZHONGBAO PHARMACY
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