Pharmaceutical composition and preparation method thereof, and hemorrhoid treating medicine

A composition and drug technology, applied in the field of medicine, can solve the problems of single drug effect, poor use adaptability, slow onset of action, etc.

Inactive Publication Date: 2017-04-26
深圳澳美制药技术开发有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to overcome the above-mentioned defects in the prior art, provide a pharmaceutical composition and its preparation method and a medicine for treating hemorrhoids, aiming to solve the problems of slow onset of action, poor adaptability to patients, and poor Technical problems with single effect

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  • Pharmaceutical composition and preparation method thereof, and hemorrhoid treating medicine
  • Pharmaceutical composition and preparation method thereof, and hemorrhoid treating medicine
  • Pharmaceutical composition and preparation method thereof, and hemorrhoid treating medicine

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preparation example Construction

[0041] Correspondingly, based on the pharmaceutical composition described above, the embodiment of the present invention also provides a method for preparing the pharmaceutical composition described above. In one embodiment, the preparation method includes the following steps:

[0042] Step S01: Weigh each raw material according to the components and contents contained in the above-mentioned pharmaceutical composition;

[0043] Step S02: pulverize the weighed raw materials of hydrocortisone, cinchocaine hydrochloride, borneol, aescin, and metronidazole;

[0044] Step S03: subject the weighed fat-soluble matrix to a hot-melt treatment, and the fat-soluble matrix after the hot-melt treatment and the hydrocortisone, cinchocaine hydrochloride, The raw materials of borneol, aescin, and metronidazole are emulsified, and then cooled and molded.

[0045] Specifically, the components and contents contained in the pharmaceutical composition in the above step S01 are as described above in the p...

Embodiment 1

[0057] This embodiment provides a suppository for treating hemorrhoids.

[0058] 1. Prescription: Hydrocortisone 7.5g, cinchocaine hydrochloride 2.5g, borneol 10g, aescin 8g, metronidazole 10g, saturated C8-C18 fatty acid glycerides composed of semi-synthetic glycerides to make up to 1800g.

[0059] 2. The preparation method of suppository for treating hemorrhoids is as follows:

[0060] The above-mentioned hydrocortisone, cinchocaine hydrochloride, borneol, aescin, and metronidazole were respectively crushed into subdivided parts for later use. The fine powder was passed through a 100-mesh sieve, the matrix was melted at 45°C, and added according to the prescription ratio The above-mentioned pulverized fine powder is emulsified by an emulsifier at 1500 rpm, and after the emulsification is completed, it is injected into the suppository production equipment and cooled, and the cooling temperature is 12° C. to obtain.

Embodiment 2

[0062] This embodiment provides a suppository for treating hemorrhoids.

[0063] 1. Prescription: hydrocortisone 7.0g, cinchocaine hydrochloride 3.0g, borneol 20g, aescin 15g, metronidazole 10g, saturated C8-C18 fatty acid glyceride composed of semi-synthetic glyceride to make up to 1800g.

[0064] 2. The preparation method of suppository for treating hemorrhoids is as follows:

[0065] The above raw materials of hydrocortisone, cinchocaine hydrochloride, borneol, aescin, and metronidazole are respectively pulverized into subdivisions for later use. The fine powder is passed through a 150-mesh sieve, the matrix is ​​melted at 48°C, and added according to the prescription ratio The above-mentioned pulverized fine powder is emulsified by an emulsifier at 2000 rpm, and after the emulsification is completed, it is injected into the suppository production equipment and cooled, and the cooling temperature is 10°C to obtain.

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Abstract

The present invention discloses a pharmaceutical composition and a preparation method thereof, and a hemorrhoid treating medicine. 1800 parts of the pharmaceutical composition comprises, by weight, 2.5-7.5 parts of hydrocortisone, 2.5-7.5 parts of dibucaine hydrochloride, 10-20 parts of borneol, 8-15 parts of escin, 5-10 parts of metronidazole, and the balance of a fat-soluble matrix. The hemorrhoid treating medicine comprises an effective therapeutic dose of the pharmaceutical composition. According to the present invention, through the synergistic effect of various components contained in the pharmaceutical composition and the hemorrhoid treating medicine, the pharmaceutical composition and the hemorrhoid treating medicine provide significant effects of bleeding stopping, swelling subsiding and pain stopping for hemorrhoid treatment, and have advantages of significant treatment effect, safety, no pain, rapid onset, convenient use, and the like.

Description

Technical field [0001] The invention belongs to the field of medicine, and specifically relates to a pharmaceutical composition and a preparation method thereof, and a medicine for treating hemorrhoids containing an effective dose of the pharmaceutical composition. Background technique [0002] Hemorrhoids are a chronic disease of one or more soft veins caused by varicose veins at the bottom of the anorectum and anal mucosa. Hemorrhoids is the most common anorectal disease in humans, and the incidence rate in my country is about 50-70%. There are many causes of hemorrhoids. Sitting for a long time, standing for a long time, fatigue, etc. make the human body stay in a fixed position for a long time, which affects blood circulation, slows blood flow in the pelvic cavity and congestion of abdominal internal organs, causing excessive hemorrhoidal vein filling, varicose, Protrusion, the tension of the vein wall decreases and causes the disease. During pregnancy, hemorrhoids often oc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61P9/14A61P29/00A61P31/04A61K31/47A61K31/045A61K31/573A61K31/4164
Inventor 张超赵燕燕刘华吴涛汤明辉李海华张志燕
Owner 深圳澳美制药技术开发有限公司
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