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Anti-shock medicament with oxygen

An anti-shock and drug technology, which is applied in the direction of drug combination, pharmaceutical formula, and non-active ingredients of polymer compounds, can solve problems such as difficulty in sustaining life and lack of oxygen supply function, so as to prevent oxygen free radical damage and improve blood flow Kinetic, Ease of Tissue Oxygen Effects

Inactive Publication Date: 2008-06-18
XIEHETONGREN TECH TIANJIN CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when there is excessive blood loss or deep shock caused by other reasons, human tissues, especially the heart, brain, kidney and other tissues need oxygen supply to save life, and only rely on pure colloid solution to expand blood circulation capacity and maintain normal circulation. it is difficult to sustain life
Existing anti-shock drugs (for example, artificial colloid solutions, etc.) do not have the function of oxygen supply, so there is an urgent need for an anti-shock drug with oxygen-carrying function in clinical practice

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0015] Embodiment: an oxygen-carrying anti-shock drug, characterized in that its basic formula is: adding nano-scale oxygen-carrying substances and ingredients for preventing adverse reactions into hydroxyethyl starch solution with a concentration of 6% and a molecular weight of 100kD.

[0016] The above-mentioned quality standards of hydroxyethyl starch HES, nano oxygen-carrying substances and components for preventing adverse reactions should meet the requirements of large-dose intravenous injection, that is, greater than 500mL of intravenous injection.

[0017] The molar substitution Ms of the above-mentioned hydroxyethyl starch is 0.5.

[0018] The above-mentioned nano oxygen-carrying substance is Polyhemoglobin Poly-Hb solution, the concentration range is 5%, its molecular weight is 80kD, and the particle radius is 22nm.

[0019] The above-mentioned ingredients for preventing adverse reactions are carbohydrates, amino acids and antioxidants.

[0020] The sugar mentioned ...

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PUM

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Abstract

Disclosed is an oxygen-laden antishock drug, which is characterized in that the essential formulation is that: nanometer-sized oxygen-laden material and adverse-reaction-preventive component are added into hydroxyethyl starch solution whose concentration is 3-10% and whose molecular weight is 20-200kD. The invention has the advantages that the good-plasma-volume-expansion effect and the capacity to supply anoxic tissue with oxygen guarantees that the anoxic condition of different organs of human body can be quickly released and corrected and the normal physiological function can be restored gradually, so that the curing purpose can be achieved; meanwhile, unhealthy tendencies like edema of vascular endothelium and inflammatory reaction caused by ischemia can be prevented and treated by adding side-effect-preventive component of certain concentration in the oxygen-laden medical solution.

Description

(1) Technical field: [0001] The invention relates to a medicine, especially an oxygen-carrying anti-shock medicine. (two) background technology: [0002] Artificial colloid solutions such as gelatin, dextran, and sodium chloride injections such as hydroxyethyl starch are commonly used effective drugs for the treatment of patients with hypovolemia and shock. However, when there is excessive blood loss or deep shock caused by other reasons, human tissues, especially the heart, brain, kidney and other tissues need oxygen supply to save life, and only rely on pure colloid solution to expand blood circulation capacity and maintain normal circulation. It is difficult to sustain life. Existing anti-shock drugs (eg, artificial colloid solutions, etc.) do not have the function of oxygen supply, and thus an anti-shock drug with oxygen-carrying function is urgently needed in clinical practice. (3) Contents of the invention: [0003] The purpose of the present invention is to design...

Claims

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Application Information

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IPC IPC(8): A61K47/42A61K47/26A61K47/22A61K47/16A61K47/10A61K47/02A61K31/718A61K33/00A61P9/02A61P43/00
Inventor 杨成民张文博梁伟光张鸿辉李涛
Owner XIEHETONGREN TECH TIANJIN CO LTD
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