Method for extracting crocetin from gardenia

Abstract

The invention relates to a preparation method of the crocetin extracted from the gardenia, which is characterized in that after the gardenia is crushed and extracted by ultrasonic enhancement in distilled water or ethanol solution, the extractant is filtered and concentrated; the glycoside substance of the gardenia is separated via the macroporous resin and the crocin eluent is concentrated and dealt with acid hydrolysis or alkaline hydrolysis (alkaline hydrolysis solution should be adjusted to pH of acidity.), centrifugal, rinse and sedimentation to get the crude product of the crocetin; after purifying the crude product of the crocetin further, the cis crocetin and the trans crocetin are separated to acquire trans crocetin of high purity which facilitates structure modification, forms a plurality of crocetin derivatives featured by different water soluble and drug efficacy, providing material for related preparation R and D and application. The preparation method of the crocetin extracted from the gardenia has the advantages of having convenient and fast method, low cost and establishing a new channel for deep processing of gardenia products.

Description

Technical field

[0001] The invention relates to a method for extracting and preparing crocetic acid from gardenia. Background technique

[0002] Gardenia is the dry mature fruit of the Rubiaceae plant Gardenia. It is mainly produced in Jiangxi, Hunan, Guangxi, Sichuan and other places. The common cultivated varieties are: Gardenia (Gardeniajasminodes Ellis), which is a pharmacopoeia specified variety; Water Gardenia (G .jasminodesEllis f.longiarpa ZWXie et Okada), a variant of gardenia, used as dyes and pigments; gardenia (double-petaled gardenia) (G.jasminodes Ellis var.fortuniana (Lind1) Ham), of gardenia Varieties, garden cultivation. At present, in addition to its application in traditional Chinese medicine, gardenia is mainly used as a raw material for extracting natural pigments for the preparation of gardenia, gardenia red, and gardenia yellow pigments. Among them, the main component of gardenia yellow pigment is crocin (Nasha, Guo Tianguo. Progress in pharmacological rese...