Molecular engram polymer for purifying 6-gingerol as well as preparation and uses thereof

A molecular imprinting and polymer technology, applied in the separation/purification of carbonyl compounds, organic chemistry and other directions, can solve the problems of insufficient 6-gingerol purity, difficult to control product purification, cumbersome raw material processing, etc. The effect of low production cost and simple regeneration method

Inactive Publication Date: 2008-09-03
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The weak point of above-mentioned method is: (1) use method 2. or 3. equipment investment is big, and product purification is difficult to control, if will be used in a large amount in production, also needs to do further research; Though use method 1. investment is low, but raw material processing loaded down with trivial details; (2) obtained 6-gingerol purity is not high enough, and its application has been subjected to certain restriction

Method used

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  • Molecular engram polymer for purifying 6-gingerol as well as preparation and uses thereof
  • Molecular engram polymer for purifying 6-gingerol as well as preparation and uses thereof
  • Molecular engram polymer for purifying 6-gingerol as well as preparation and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The flow chart of the preparation and application of the molecularly imprinted polymer for purifying 6-gingerol of the present invention is as follows figure 1 shown.

[0038] (1) material preparation

[0039] The components of this embodiment are prepared according to the following dosage ratio: template molecule (6-gingerol) 3.42g, functional monomer (methacrylic acid) 3.66g, crosslinking agent (ethylene glycol dimethacrylate) 28.96g , Initiator (azobisisobutyronitrile) 0.31g, solvent (diethyl ether and acetonitrile weight ratio is 1: 1 mixed solvent) 63.65g.

[0040] (2) Preparation of molecularly imprinted polymers with template molecule 6-gingerol

[0041] Add the mixed solvent of template molecule 6-gingerol, methacrylic acid, ethylene glycol dimethacrylate, azobisisobutyronitrile and ether and acetonitrile prepared in (1) into the reaction kettle and mix evenly, then pass After the nitrogen flow rate was 0.1ml / ml.min, ultrasonic degassing was used for 3 minute...

Embodiment 2

[0048] (1) material preparation

[0049] The components of this embodiment are prepared according to the following dosage ratio: template molecule 6-gingerol 2g, functional monomer (4-vinylpyridine) 3g, crosslinking agent (N, N-diylidene diacrylamide) 26g, 0.2 g of initiator (benzoyl peroxide), and 68.8 g of solvent (mixed solvent with a weight ratio of toluene and isooctane of 2:1).

[0050] (2) Preparation of molecularly imprinted polymers with template molecule 6-gingerol

[0051] Add the template molecule 6-gingerol, 4-vinylpyridine, N, N-diylidene diacrylamide, benzoyl peroxide and the mixed solvent of toluene and isooctane into the reaction kettle prepared in (1) Mix evenly, then pass through the nitrogen flow rate of 0.5ml / ml.min, and then use ultrasonic degassing for 10 minutes, and then seal and react in a constant temperature water bath at 50°C for 10 hours to obtain a molecularly imprinted polymer with template molecule 6-gingerol, and then It is ground and passed...

Embodiment 3

[0058] (1) material preparation

[0059] The components of this embodiment are prepared according to the following dosage ratio: template molecule 6-gingerol 4g, functional monomer (vinylimidazole) 6g, crosslinking agent (pentaerythritol tetramethacrylate) 30g, initiator (benzene peroxide Formyl) 0.4g, solvent (mixed solvent with a weight ratio of tetrahydrofuran and isooctane of 3.5:1) 59.6g.

[0060] (2) Preparation of molecularly imprinted polymers with template molecule 6-gingerol

[0061] Add the template molecule 6-gingerol, vinylimidazole, pentaerythritol tetramethacrylate, benzoyl peroxide and the mixed solvent of tetrahydrofuran and isooctane prepared in (1) into the reaction kettle and mix evenly, then pass into After the nitrogen flow rate is 1ml / ml.min, use ultrasonic degassing for 20min, and then seal and react in a constant temperature water bath at 60°C for 24h to obtain a molecularly imprinted polymer with template molecule 6-gingerol, and then grind it throug...

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Abstract

The invention discloses a preparation and application technique of molecular engram polymer for purifying 6-gingerol. The 6-ginerol, function monomer, crosslinking agent, initiator and solvent are mixed together in reaction kettle and reacted at constant temperature after degassing to obtain molecular engram polymer with template. The molecular engram polymer is subjected to grinding and screening to produce uniform molecular engram polymer granules with templates. The templates are washed away using organic solvent and dried to obtain molecular engram polymer for purifying 6-gingerol. The molecular engram polymer is used as column chromatography filling material to fill the column and the ginger juice is added into the column chromatography, the alcohol solution is used to elute, and then the elution liquid is concentrated and the alcohol is recovered, the 6-gingerol is finally obtained after extracting. The molecular engram polymer for purifying 6-gingerol has features of high selectivity, large adsorptive capacity and regeneration and the purity of 6-gingerol purified by the method can be about 95%.

Description

technical field [0001] The invention belongs to the field of preparation of natural products or bioactive components, in particular to a preparation method and application of a molecularly imprinted polymer for purifying 6-gingerol. Background technique [0002] The molecular formula of 6-gingerol is C 17 h 26 o 4 , the molecular weight is 294.40, and it is a pale yellow oil. It is an important spicy ingredient in ginger (Zingiber officinale Roscoe), which has various biological activities such as anti-oxidation, anti-AIDS, anti-mutation, anti-inflammation, anti-rheumatism, anti-tumor, anti-emetic, anti-dizziness, and cold repellent. It can be used to produce drugs and health food for treating cardiovascular and cerebrovascular diseases, rheumatoid arthritis, gastric ulcer and other diseases. [0003] In order to make full use of the pharmacology and health care effects of 6-gingerol, people have done a lot of research on its industrial production methods. The method th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F20/06C08F26/06C08F251/00C08F2/44C08J9/26C07C49/255C07C45/78
Inventor 黄雪松闫金奎
Owner JINAN UNIVERSITY
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