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Racecadotril dropping pill and preparation thereof

A technology of racecadotril and racecadotril, which is applied in pill delivery, digestive system, and pharmaceutical formulations, can solve problems such as slow absorption and distribution, low bioavailability, and complicated production process, and achieve low production cost, Low labor intensity and the effect of increasing the contact area

Inactive Publication Date: 2008-09-17
YANCHENG SUHAI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] The purpose of the present invention is to overcome the defects of low solubility, low bioavailability, slow absorption and distribution in the body, complex production process, high cost and large pollution of the existing racecadotril preparation dosage form, and provide a bioavailability Oral preparation racecadotril dripping pills with high, rapid drug release, rapid effect, simple production process, low production cost, no pollution in the production process, and high yield and preparation method thereof

Method used

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  • Racecadotril dropping pill and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A kind of racecadotril drop pill, with racecadotril as raw material, polyethylene glycol 4000 With polyoxyl 40 stearate as a base, in g or Kg, in parts by weight, racecadotril: polyethylene glycol 4000 : Polyoxyl 40 stearate = 1: 1: 1 ratio prepared.

[0031] Its preparation method is:

[0032] 1. According to the ratio given in the formula, accurately weigh dexcadotril and polyethylene glycol 4000 With polyoxyl 40 stearate, they are placed in a heating container and heated while stirring until the melt and / or emulsion and / or suspension containing racecadotril and matrix are obtained for subsequent use;

[0033] 2. Use a general-purpose dripping pill machine, adjust the temperature control system of the dripping pill machine, so that the temperature of the dripper of the dripping pill machine is heated and maintained at 50-90 °C. Use liquid paraffin as the condensing agent, adjust the temperature of the condensing agent to cool and keep it at 40-0°C;

[0034] 3. Whe...

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PUM

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Abstract

The invention provides a racecadotril pill which is a composition used for curing acute diarrhea. The racecadotril pill takes g or Kg as the unit and adopts the weight ratio that racecadotril to polyethylene glycol (4000 to 10000) to polyoxyethylene (40) stearate is equal to 1: 1: 1 to 1: 3: 3. The invention also relates to a preparation method, which means that pro rata matching -> making melt liquid and / or emulsion and / or suspension by heating for standby -> adjusting the temperature control system of pill machine -> dropping pill and forming -> removing condensing agent and drying. The racecadotril pill has the advantages of high bioavailability, rapid releasing speed and rapid marked effect. The preparation method of racecadotril pill has the advantages of simple production technology, low production cost, non-pollution of production process and high yield.

Description

technical field [0001] The invention relates to a medicinal organic composition for treating acute diarrhea and a preparation method thereof, in particular to a medicinal combination oral preparation prepared with racecadotril as an active substance and a preparation method thereof. Background technique [0002] Diarrhea is a common disease with high morbidity and mortality, not only in developing countries, but also in western developed countries. The most common cause of diarrhea is an intestinal infection, and infants, preschoolers, teenagers, and those with congenital or acquired immunodeficiency are at high risk for this infection. Diarrhea can be roughly divided into three categories according to its clinical symptoms: acute watery diarrhea, bloody diarrhea, and persistent diarrhea. At present, oral rehydration and inhibition of peristalsis are mainly used to treat diarrhea clinically. Oral supplementation of water and electrolytes can increase the absorption of water...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/223A61K47/30A61P1/12
Inventor 徐俊福陆斌缪建国
Owner YANCHENG SUHAI PHARMA
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