Magnetic target carrier system
A carrier system and magnetic technology, applied in the direction of antibodies, medical preparations with inactive ingredients, pharmaceutical science, etc., can solve the problems of high magnetic field strength, limited external magnetic field positioning function, and poor health of patients who are sick, and achieve good positioning. Effect
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Embodiment 1
[0024] Example 1 Magnetic targeting carrier system (in vitro adsorption of EPC or EC, under the action of magnetic field in vivo, magnetic targeting drug is adsorbed on the surface of the stent)
[0025] 1. Preparation of magnetic beads
[0026] Take 20 grams of magnetic material Fe 3 o 4 Dissolve magnetic powder and 2 grams of polyethylene glycol in 74 grams of ethanol, transfer to a three-necked bottle with a condenser, a stirrer and a nitrogen inlet, pass nitrogen, stir at 65 °C and 300 r / min for 30 minutes, and raise the temperature to 70 °C ℃, add 19.78 grams of styrene, 2 grams of maleic anhydride, 1.37 grams of acrylic acid, 0.25 g of divinylbenzene, 6 grams of benzoyl peroxide, nitrogen, 70 degrees Celsius, stirring speed 300r / min, reaction 12 Hours to complete collection of magnetic beads. The particle size of the magnetic beads is about 50nm.
[0027] 2. Magnetic targeting drugs
[0028] With magnetic beads as the core, add 480mg-820mg of fibrinogen which contai...
Embodiment 2
[0033] Example 2 (Under the action of a magnetic field in the body, the magnetically targeted drug is adsorbed on the surface of the stent, and the antibody adsorbs EPC or EC in the body)
[0034] 1. Preparation of carboxylated magnetic particles
[0035] Add 1.61g 2.5% W / V magnetic particles (cobalt powder material), 1g sodium lauryl sulfate, 10g potassium persulfate and a mixture containing 0.98mL undecylenic acid and 0.02mL divinylbenzene in 4mL methanol The solution is carboxylated. The mixture was in a sealed bottle and centrifuged at 55° C. at 60 rpm for 5 hours under vacuum. The generated carboxylated magnetic particles were respectively magnetized and washed several times with deionized water until the supernatant was clear. Carboxylated magnetic particles were added to 680 mL of deionized water to resuspend a 5.8% W / V suspension with an average diameter of 4.3 microns.
[0036] 2. Preparation of magnetically targeted drugs
[0037] In a 4 mL cuvette, place 1 mL of...
Embodiment 3
[0041] Example 3 (Using a magnetic field to adsorb magnetically targeted drugs on the surface of the stent before implantation, and the antibody adsorbs EPC or EC in vivo) The preparation steps 1, 2, and 3 are the same as in Example 2, and the magnetic stent is made of 316L stainless steel.
[0042] Under the action of an external magnetic field, the magnetic targeting drug is adsorbed on the surface of the stent, and then implanted into the patient. The antibody goat anti-mouse IgG on the surface of the stent can adsorb and capture the autologous endovascular cells EPC or EC.
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