Magnetic target carrier system

A carrier system and magnetic technology, applied in the direction of antibodies, medical preparations with inactive ingredients, pharmaceutical science, etc., can solve the problems of high magnetic field strength, limited external magnetic field positioning function, and poor health of patients who are sick, and achieve good positioning. Effect

Inactive Publication Date: 2008-09-17
BEIJING ZHONGFU YOUXIN MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Most of the existing magnetic targeting drug carriers achieve the purpose of positioning drug delivery through the guidance of the external magnetic field, but the positionin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1 Magnetic targeting carrier system (in vitro adsorption of EPC or EC, under the action of magnetic field in vivo, magnetic targeting drug is adsorbed on the surface of the stent)

[0025] 1. Preparation of magnetic beads

[0026] Take 20 grams of magnetic material Fe 3 o 4 Dissolve magnetic powder and 2 grams of polyethylene glycol in 74 grams of ethanol, transfer to a three-necked bottle with a condenser, a stirrer and a nitrogen inlet, pass nitrogen, stir at 65 °C and 300 r / min for 30 minutes, and raise the temperature to 70 °C ℃, add 19.78 grams of styrene, 2 grams of maleic anhydride, 1.37 grams of acrylic acid, 0.25 g of divinylbenzene, 6 grams of benzoyl peroxide, nitrogen, 70 degrees Celsius, stirring speed 300r / min, reaction 12 Hours to complete collection of magnetic beads. The particle size of the magnetic beads is about 50nm.

[0027] 2. Magnetic targeting drugs

[0028] With magnetic beads as the core, add 480mg-820mg of fibrinogen which contai...

Embodiment 2

[0033] Example 2 (Under the action of a magnetic field in the body, the magnetically targeted drug is adsorbed on the surface of the stent, and the antibody adsorbs EPC or EC in the body)

[0034] 1. Preparation of carboxylated magnetic particles

[0035] Add 1.61g 2.5% W / V magnetic particles (cobalt powder material), 1g sodium lauryl sulfate, 10g potassium persulfate and a mixture containing 0.98mL undecylenic acid and 0.02mL divinylbenzene in 4mL methanol The solution is carboxylated. The mixture was in a sealed bottle and centrifuged at 55° C. at 60 rpm for 5 hours under vacuum. The generated carboxylated magnetic particles were respectively magnetized and washed several times with deionized water until the supernatant was clear. Carboxylated magnetic particles were added to 680 mL of deionized water to resuspend a 5.8% W / V suspension with an average diameter of 4.3 microns.

[0036] 2. Preparation of magnetically targeted drugs

[0037] In a 4 mL cuvette, place 1 mL of...

Embodiment 3

[0041] Example 3 (Using a magnetic field to adsorb magnetically targeted drugs on the surface of the stent before implantation, and the antibody adsorbs EPC or EC in vivo) The preparation steps 1, 2, and 3 are the same as in Example 2, and the magnetic stent is made of 316L stainless steel.

[0042] Under the action of an external magnetic field, the magnetic targeting drug is adsorbed on the surface of the stent, and then implanted into the patient. The antibody goat anti-mouse IgG on the surface of the stent can adsorb and capture the autologous endovascular cells EPC or EC.

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PUM

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Abstract

The invention relates to a magnetic targeting carrier system, belonging to the technical field of biotechnology, comprising a magnetic targeting drug and a magnetic targeting bracket. The magnetic targeting carrier system is characterized in that: the magnetic targeting drug comprises a magnetic core, a carrier and a drug for repairing tunica intima. The magnetic targeting carrier system directs the drug on the lesion site through a magnetic implanted bracket. The magnetic targeting carrier system has the advantages of excellent drug targeting positioning, and ability to administrate according to needs without applying magnetic field for human body, not only suitability for coronary heart disease, but also reference function for therapy of local lesion such as tumor, and cancers.

Description

Technical field: [0001] The invention relates to the field of biotechnology, in particular to a magnetic carrier system used for carrying, solidifying and releasing medicine. Background technique [0002] Looking for a carrier that can carry drugs, radioactive substances, proteins, polypeptides, nucleotides, genes, plasmids, antibodies, cytokines, cells, and tissues to the diseased site for local release, and control the release speed and quantity ( CARRIER, ORPOLYMER) has always been a hot spot and difficulty in the field of biotechnology research. [0003] In the early stage of coronary artery stenosis, patients with coronary heart disease can be cured by implanting a stent at the narrowed heart vessel to expand the narrowed area. However, after implantation of common stents, when the narrow blood vessel segment with disease occurs is expanded by pressure, the intima of the blood vessel may be damaged. Damaged vascular intima stimulates the body not only to produce throm...

Claims

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Application Information

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IPC IPC(8): A61K39/395A61K47/36A61K47/42A61K47/24A61K47/32A61K47/34A61K47/02A61L31/12A61L31/16A61F2/82
Inventor 侯东明张建军
Owner BEIJING ZHONGFU YOUXIN MEDICAL TECH
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