Method for diagnosing and treating renal cell carcinoma

Abstract

Objective methods for detecting and diagnosing renal cell carcinoma (RCC) are described herein. In one embodiment, the diagnostic method involves determining the expression level of RCC-associated gene that discriminates between RCC cells and normal cells. The present invention further provides methods of screening for therapeutic agents useful in the treatment of renal cell carcinoma, methods of treating renal cell carcinoma and method of vaccinating a subject against renal cell carcinoma.

Description

[0001] This application claims the rights to the U.S. Provisional Application Serial No. 60 / 703,640 filed on July 28, 2005 and the U.S. Provisional Application Serial No. 60 / 799,960 filed on May 11, 2006. The entire contents of these applications are incorporated herein as reference. Technical field [0002] The present invention relates to methods of diagnosing and treating renal cell carcinoma. Background technique [0003] Renal cell carcinoma (RCC) is the third most common malignant tumor of the genitourinary system, accounting for 2 to 3% of all human malignancies. At present, surgical resection is the most effective treatment for localized RCC tumors, but there is no satisfactory effective treatment for patients with advanced RCC. Although the effective rate of some RCC-related therapies can reach about 20%, serious side effects frequently occur, and the patient's prognosis has not improved overall (Ljungberg B, et al., (1999) BJU Int. 84:405-11; LevyDA , Et al. (1998) J Uro...

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[0009] Peptide-stimulated peripheral blood mononuclear cells (PBMCs) from certain healthy donors have repeatedly been reported to produce significant levels of IFN-γ in response to peptides, but in 51 Cr-release assays are rarely cytotoxic to tumor cells in an HLA-A24 or A0201 restricted manner (Kawano K et al. (2000) Cancer Res 60:3550-8.; Nishizaka S et al. (2000) Cancer Res 60: 4830-7.; Tamura M et al. (2001) Jpn J Cancer Res 92:762-7.)

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