Potassium sodium dehydroandroan drographolide succinate microcapsule and method for preparing injection thereof

Abstract

The invention relates to a medicinal microcapsule, taking the potassium sodium dehydroandroan drographolide succinate as medicinal active component, which is characterized in that the potassium sodium dehydroandroan drographolide succinate is coated by macromolecular polysaccharide membrane into the microcapsule. The invention also relates to a preparation method for potassium sodium dehydroandroan drographolide succinate injection; the potassium sodium dehydroandroan drographolide succinate is coated by the macromolecular polysaccharide membrane into the microcapsule and then made into the injection. The invention adopts the micro-capsule embedding technique to process the raw materials of the potassium sodium dehydroandroan drographolide succinate, thereby greatly improving the stability of the potassium sodium dehydroandroan drographolide succinate in aqueous solution, ensuring the mass stability of parenteral solution produced and being favorable for storing the product for a longtime.

Description

Yanhuning microcapsule and production method thereof technical field The invention relates to a drug microcapsule preparation, in particular to a method for preparing a stable Yanhuning injection from the drug microcapsule. It belongs to the field of medicine. Background technique Yanhuning is the plant Andrographis paniculata extract-andrographolide refined through esterification, dehydration, and salt formation, and it is dehydrated andrographolide half-ester potassium succinate sodium salt. The chemical name of Yanhuning is 14-dehydro-11,12-didehydroandrographolide-3,19-disuccinic acid half ester potassium sodium salt. Yanhuning can inhibit early capillary permeability increase and inflammatory exudation and edema, can specifically stimulate the pituitary-adrenal cortex function, promote the release of ACTH, and increase the biosynthesis of ACTH in the anterior pituitary; The effect of various viruses such as viruses, influenza viruses, respiratory viruses, etc. It i...

AI Technical Summary

Problems solved by technology

Most of the Yanhuning injections currently on the market have serious quality problems after half a year of storage. This is determined by the physical and chemical properties of the raw materials of Yanhuning. Yanhuning is very unstable in aqueous solution. It is easy to be oxidized and hydrolyzed, and the color of the solution is deepened, the content is significantly reduced, the related substances exceed the standard, and the pH value is lowered and other quality problems

Although many manufacturers add a large number of additives in the production process to stabilize the changes in raw materials and improve the quality of drugs, the effect is minimal

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