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A method for preparing refined deoiled phospholipids for producing medicinal high-purity phosphatidylcholine

A technology of high-purity phosphatidylcholine and phospholipids, which is applied in the preparation of refined deoiled phospholipids and the field of refined deoiled phospholipids. It can solve the problems of high content of lysolecithin, low content of acetone insolubles, complex extraction process, etc., and achieve lysophospholipids The effect of low acetylcholine content, low peroxide value, and high purity

Active Publication Date: 2018-10-26
河北德嵩生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The deoiled phospholipids obtained in the prior art all have problems such as low acetone insolubles, high peroxide value, and high content of lysolecithin. Alkaline and soybean oil-removing process steps, resulting in complex and cost-prohibitive extraction processes

Method used

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  • A method for preparing refined deoiled phospholipids for producing medicinal high-purity phosphatidylcholine
  • A method for preparing refined deoiled phospholipids for producing medicinal high-purity phosphatidylcholine
  • A method for preparing refined deoiled phospholipids for producing medicinal high-purity phosphatidylcholine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-3

[0025] Example 1-3 Adding citric acid to prepare refined deoiled phospholipids

Embodiment 1

[0027] In the extraction tank of 1500L, first add 800L of acetone with a purity of 99.5%, feed nitrogen into the extraction tank to remove the air, then add 80gTBHQ and 800g citric acid, start stirring, the stirring speed is 600r / min, slowly add 200kg of liquid phospholipid ( Acetone insoluble matter 62.3%, LPC 1.12%, peroxide value 0.3), turn on the condensed water, control the extraction temperature within 15°C, and extract and stir for 30 minutes.

[0028] After static precipitation for 30 minutes, extract 400L of the upper layer mother liquor, then add 400L of acetone with a purity of 99.5%, pass nitrogen into the extraction tank to remove the air, then add 40g of TBHQ and 400g of citric acid, start stirring, and extract for 20 minutes. Repeat the above steps 4 times.

[0029] After extracting 400L of the upper mother liquor, add 400L of acetone with a purity of 99.5%, pass nitrogen into the extraction tank to remove the air, then add 40g of TBHQ, start stirring, and extra...

Embodiment 2

[0032]In the extraction tank of 1500L, first add 600L of acetone with a purity of 99.5%, feed nitrogen into the extraction tank to remove the air, then add 80gTBHQ and 800g citric acid, start stirring, the stirring speed is 400r / min, slowly add 200kg of liquid phospholipid ( Acetone insoluble matter 62.3%, LPC 1.12%, peroxide value 0.3), turn on the condensed water, control the extraction temperature within 20°C, and extract and stir for 40 minutes.

[0033] After static precipitation for 30 minutes, extract 400L of the upper layer mother liquor, then add 400L of acetone with a purity of 99.5%, pass nitrogen into the extraction tank to remove the air, then add 40g of TBHQ and 400g of citric acid, start stirring, and extract for 20 minutes. Repeat the above steps 4 times.

[0034] After extracting 400L of the upper mother liquor, add 400L of acetone with a purity of 99.5%, pass nitrogen into the extraction tank to remove the air, then add 40g of TBHQ, start stirring, and extrac...

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Abstract

The invention provides a method for preparing refined deoiled lecithin which has a light color, a low peroxidation value, high acetone-insoluble substance content and low lysophosphatidylcholine content. The method is simpler and more convenient, low in cost and suitable for large-scale industrial production and comprises steps as follows: repeated extraction, centrifugal separation, drying and the like.

Description

technical field [0001] The invention relates to a method for refining deoiled phospholipids, in particular to a method for preparing refined deoiled phospholipids for producing medicinal high-purity phosphatidylcholine, and belongs to the technical field of chemical purification. Background technique [0002] Phospholipids are a class of phosphorus-containing fatty substances that exist in the biological world. It is composed of acyl inositol (inositol phospholipid, PI) and phosphatidic acid (PA). Phospholipids are natural emulsifiers and surfactants with high nutritional value and special physiological properties, and can be widely used in medicine, food, feed, fiber, cosmetics, leather, dyeing, chemical industry, environmental protection and other fields. Phospholipids are not resistant to high temperature. They start to turn brown at 80°C and decompose at 120°C. Among them, phosphatidylcholine is one of the main components of phospholipids. It is an amphiphilic molecule...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07F9/10
CPCC07F9/103
Inventor 吕鹏姗王彦葛萌段妍聪
Owner 河北德嵩生物科技有限公司