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Prevascularized devices and related methods

A vascularization and microvascular technology, applied in pre-vascularization devices and related fields, can solve the problems such as the loss of β-cell viability and function

Inactive Publication Date: 2008-10-08
亚利桑那董事会
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there remains a major limitation associated with this therapy - loss of beta cell viability (viability) and function due to lack of blood supply to support cell survival
Although whole-organ allografting of the pancreas has an expected graft survival rate of greater than 80% per year, the risk of severe postoperative complications as well as the risk of chronic immunosuppression limit this approach

Method used

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  • Prevascularized devices and related methods
  • Prevascularized devices and related methods
  • Prevascularized devices and related methods

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Experimental program
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Embodiment

[0085] summary

[0086] An important goal of medical techniques for islet cell transplantation that avoids the use of immunosuppressive drugs is the treatment of diabetic hyperglycemia. These experiments evaluated new immunoisolating devices constructed using the formed microcirculation. The ability to maintain islet cell viability in vivo using this prevascularized construct was examined. The cell transplantation methods investigated were compatible with the human operating room and the feasibility of transferring these preclinical studies to the human clinical setting (condition) for diabetes treatment was evaluated.

[0087] Evaluation of PVID

[0088] Because of the time required to restore and establish a stable vasculature, any device or tissue implantation is at risk of early failure. The inventors of the present invention have developed methods for the preformation of an adaptive microvasculature capable of rapidly developing into a mature and efficient perfusio...

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Abstract

The present invention provides an implantable devices for providing a biologically active agent to a subject in need thereof, the device comprising a microvessel construct in contact with a biocompatible, semi-permeable pouch, the pouch encapsulating a cell or cells capable of producing the biologically active agent. The present invention also provides methods for treating or preventing a disorder in a subject using the implantable device. The present invention also provides specific methods for treating or preventing diabetes in a subject comprising implanting in the subject an immunoisolation device comprising a microvessel construct in contact with a biocompatible, semi-permeable pouch, the pouch encapsulating a cell or cells capable of producing a therapeutically effective amount of insulin. Methods for vascularizing and revascularizing tissue, including engineered tissue, are also provided.

Description

[0001] Related Application Cross Reference [0002] This application claims priority to US Provisional Application No. 60 / 686,706, filed June 2, 2005, which is hereby incorporated by reference in its entirety. technical field [0003] The present disclosure broadly relates to devices and methods for increasing the efficacy of cell-based therapies through the use of prevascularized constructs, including significantly prolonging the viability of implanted cells and functional devices and immune isolation devices. Background technique [0004] Diabetes mellitus is a group of diseases characterized by high blood glucose levels caused by defects in insulin production, insulin action, or both. Currently, an estimated 20.8 million people in the United States, or about 7 percent of Americans, have diabetes, and the incidence of the disease is increasing. [0005] The major types of diabetes include type 1 diabetes (or type I diabetes), type 2 diabetes (or type II diabetes), gestat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N65/00A01N63/00A61K35/39A61K35/44
CPCA61K35/39A61K35/44A61M5/14276A61L27/3804A61L27/3891A61K9/0024A61P3/10A61P9/00B60N2/01583B60N2/06B60N2/22B60N2/3011B60N2/3031B60N2/305B60N2/309B60N2/838B60N2/856B60N2205/40
Inventor 斯图尔特·K·威廉姆斯詹姆斯·B·霍伊英
Owner 亚利桑那董事会