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Medicament for easing pain and eliminating tumour and preparation method thereof

A drug and tumor-eliminating technology, applied in anti-tumor drugs, drug combinations, pharmaceutical formulations, etc., can solve the problems of insufficient carrier safety, elevated ALT, unfavorable onset of effects, etc., and achieve longer administration time, better blood drug concentration, Toxicity reduction effect

Inactive Publication Date: 2008-10-29
UNIV OF SCI & TECH OF CHINA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main ingredients of the drugs involved in the first four patent documents contain realgar, which is also an ointment, but they are all compound recipes composed of various traditional Chinese medicines, and they are only passed through a 200-mesh sieve. Too large a particle size is not conducive to onset of effect, and The carrier in the ointment is not safe enough
The compound Huangdai tablet involved in the fifth patent document is an oral tablet. Large and medium doses can cause an increase in ALT, indicating that it has certain liver toxicity, and it is only used in the treatment of blood diseases.

Method used

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  • Medicament for easing pain and eliminating tumour and preparation method thereof
  • Medicament for easing pain and eliminating tumour and preparation method thereof
  • Medicament for easing pain and eliminating tumour and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1, preparation analgesic and eliminating tumor ointment

[0034] Bake realgar (Haozhou Jingde Pharmaceutical Co., Ltd.) and ginger, put them into a low-temperature ball mill, work at 2000-4000rpm for 5 minutes, stop for 15 minutes, work for 5 minutes under the same conditions, repeat 6-7 times, and ensure that the work The temperature is less than 40°C, and the realgar and ginger are processed into nanoparticles. The processed realgar and ginger particles were dissolved in water, and the realgar and ginger particles and particle size were observed under a transmission electron microscope (JEM-2011 JOEL, Tokyo).

[0035] The result is as figure 1 As shown, it shows that realgar and ginger particle size is 60-100nm, figure 1 The middle scale bar is 60 nm.

[0036] Take processed 50g of realgar granules, 50g of ginger granules and 200g of carrier into the emulsifier, emulsify for 5min at 6000-8000rpm (radius of rotation is 1-2cm), then stop for 15min, then wo...

Embodiment 2

[0038] Embodiment 2, preparation analgesic and eliminating tumor ointment

[0039] Realgar and ginger were made into particles of 60-200nm according to the method in Example 1.

[0040] Get processed 50g of realgar granules and 75g of ginger granules and 250g of carrier, mix and emulsify according to the method in Example 1 to form a finished product.

[0041] The carrier is made by mixing the following ingredients at 50-70°C: 20g glycerol monostearate, 2.5g hydroxypropyl methylcellulose, 25g isopropyl myristate, 2.5g methylparaben, 2.5 g propylparaben, 30 g polyoxyl-40-stearate and 167.5 g normal saline.

Embodiment 3

[0042] Embodiment 3, preparation analgesic and eliminating tumor ointment

[0043] Realgar and ginger were made into particles of 60-200nm according to the method in Example 1.

[0044] Get processed 75g of realgar granules and 50g of ginger granules and 250g of carrier and mix and emulsify according to the method in Example 1 to form a finished product.

[0045] The carrier is made by mixing the following ingredients at 50-70°C: 22.5g glycerol monostearate, 2.5g hydroxypropyl methylcellulose, 25g isopropyl myristate, 1.25g methylparaben, 1.25g propylparaben, 30g polyoxyl-40-stearate, 167.5g normal saline.

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Abstract

The invention discloses a drug for relieving pain and eliminating tumor and a preparation method thereof. The active ingredients of the drug for relieving pain and eliminating tumor are realgar and ginger, the weight ratio of the realgar and the ginger is (1 to 3): (1 to 3); and the particle size of the realgar and the ginger is 60 to 500nm. The drug further comprises a carrier, and the weight ratio of the realgar, the ginger and the carrier is (1 to 3): (1 to 3): (4 to 10). The drug for relieving pain and eliminating tumor can be prepared into a cream for relieving pain and eliminating tumor after being added the carrier. The drug for relieving pain and eliminating tumor of the invention has insignificant toxicity and side effects, and the plasma-drug concentration is stable.

Description

technical field [0001] The invention relates to an analgesic and antitumor drug and a preparation method thereof. Background technique [0002] At present, the traditional Chinese medicine preparations related to analgesic and antitumor mainly include the following documents: Chinese invention patent CN1133725 discloses cancer tumor reducing swelling and pain relief ointment; Ai Xiaoliu Paste, Chinese invention patent CN1153645 discloses skin cancer powder, skin cancer ointment, Xiaoyao powder flavored and its preparation, and Chinese invention patent CN1615970 discloses an anti-leukemia traditional Chinese medicine compound Huangdai tablet and its preparation method. The main ingredients of the drugs involved in the first four patent documents contain realgar, which is also an ointment, but they are all compound recipes composed of various traditional Chinese medicines, and they are only passed through a 200-mesh sieve. Too large a particle size is not conducive to onset of...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K9/06A61K9/70A61K47/38A61P35/00A61P29/00A61K35/36A61K33/36
Inventor 赵奇红温龙平张颖刘赟周红英周绪天
Owner UNIV OF SCI & TECH OF CHINA
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