Preparation of silver-loaded silica-chitosan compound anti-bacteria agent

Abstract

The invention relates to a preparing method for a silver-loaded silicon dioxide-chitosan compound antibacterial agent; the preparing method comprises the following steps: silver-loaded silicon of inorganic antibacterial agent is firstly prepared according to the antibacterial and bacteriostatic characteristics of the antibacterial agent; Ag-SiO2 is used as a carrier to prepare inorganic-organic compound antibacterial agent, namely, the silver-loaded silicon dioxide-chitosan compound antibacterial agent uses silicon dioxide as inorganic material, uses polymer chitosan as organic material, uses deionized water, silver nitrate, ammonia water, KH-550, glacial acetic acid, diluted hydrochloric acid, glutaric dialdehyde and absolute ethyl alcohol as agents, carries out chemical reaction by water bath synthesis, adjusts the pH value, carries out centrifugal separation, is washed, filtered and dried in vacuum, and finally the powdered product which is white, has laminated form, layered shape and crosslink structure is prepared. The preparing method has short technique process, little used equipment, rich material source and low cost; the purity of the product can be up to 97 percent, the yield of the product can be up to 98 percent, and compared with the product with single ingredient in the prior art, the antibacterial and bacteriostatic characteristics of the product can be improved by 90 percent; therefore, the preparing method of the invention is an ideal preparing method for the inorganic-organic compound antibacterial agent.

Description

technical field [0001] The invention relates to a method for preparing a silver-loaded silica-chitosan composite antibacterial agent, belonging to the technical field of preparation and application of inorganic-organic composite antibacterial materials. Background technique [0002] The research on antibacterial agents began in the 1980s, and antibacterial agents can be divided into three categories: organic, inorganic, and compound antibacterial agents. [0003] The organic antibacterial agent is a combination of positively charged organic molecular chains and anions on the surface of the cell membranes of bacteria and fungi to react with sulfhydryl groups, destroying the cell membranes of harmful microorganisms, leading to the death of bacteria, thereby achieving the purpose of bacteriostasis and sterilization. It has the advantages of strong force, fast speed, rich material sources, good color stability, and clear antibacterial spectrum, but has disadvantages such as poor...

AI Technical Summary

Problems solved by technology

[0006] An ideal antibacterial agent should have quick-acting, long-acting, broad-spectrum, stable, and safe antibacterial effects. At present, the inorganic and organic antibacterial agents prepared and used still have some disadvantages, and have not yet achieved the desired effect. Some Preparation method and application effect still need to be further explored, for example: 20051001864812 patent, chitosan and metal zinc, the antimicrobial agent chitosan / zinc, chitosan / copper antimicrobial agent that the research such as Wuhan University Du Yumin coordinates synthesis, although It has broad-spectrum antibacterial properties, but it still has the defects of natural antibacterial agents. Its heat resistance and drug effect persistence are poor, and its application is limited; for example: Zhan Xuejun of Jiangxi Medical Science Institute et al. Chemically modify chitosan to obtain water-soluble carboxymethyl chitosan silver composite antibacterial agent, which has a certain inhibitory effect on the bacteria of burn infection, but the requirement for chitosan must be water-soluble, and The selectivity to strains is also relatively limited, so it cannot be widely used in other antibacterial fields

Images