Chinese traditional injection preparation for treating cancer and its preparation method

Abstract

The invention discloses a Chinese traditional medicinal injection for curing cancers and a preparation method thereof. The Chinese traditional medicinal injection is prepared from 0.9 to 2.1 parts of cantharis, 30 to 70 parts of ginseng, 60 to 140 parts of milk veteh and 90 to 210 parts of acanthopanax. Ginseng, milk veteh and acanthopanax are aqueously extracted and ethanol extracted respectively. The extracted solution is condensed, and micro-filtered with an inorganic ceramic membrane before the extracted solution is refined with polyamide resin; then the refined solution is hyperfiltrated with an organic membrane, and is mixed with aqueous extract of cantharis. In this way, the Chinese traditional medicine injection is prepared. By comparing the invention with the prior art, in the method for preparing the Chinese traditional medicine injection, the medicinal materials are aqueously extracted and ethanol extracted; the extracted solution is purified, separated and condensed by combining the membrane separation technology and refining with resin; accordingly, the Chinese traditional medicine injection is rich in effective ingredients. By substituting the physical method for the traditional chemical process, macromolecular substance in the extracted solution of the Chinese traditional medicine can be effectively removed without introducing other inorganic ions, thus keeping the characteristics of the compound preparation of the Chinese traditional medicine, and effectively reducing the adverse effect of the medicaments, improving the curative effect, and improving and ensuring the product quality.

Description

Technical field: The invention relates to a traditional Chinese medicine injection preparation for treating cancer and a preparation method thereof, belonging to the technical field of traditional Chinese medicine pharmacy. Background technique: Traditional Chinese medicine injection preparations are sterilized preparations made from Chinese medicinal materials through extraction, separation, refining and other steps. It has changed the traditional way of administering traditional Chinese medicine. It has rapid drug effect, high bioavailability, and more accurate dosage. It is suitable for cases that are not suitable for oral administration or acute and severe cases. It has played a good role in the treatment of acute, severe and difficult diseases by traditional Chinese medicine. However, with the increasing clinical application, the incidents of adverse drug reactions caused by traditional Chinese medicine injections have occurred frequently, which has attracted the atten...

AI Technical Summary

Problems solved by technology

The applicant disclosed the preparation process of Aidi injection in "Traditional Chinese Medicine Injection Preparation for Treating Tumors and Its Preparation Method" with the patent number 03117114.1: using ginseng alcohol and water extraction, and the remaining three flavors water extraction, lime sulfur precipitation treatment, alcohol Shen's method to obtain active ingredients, the method is simple in composition, the loss of effective drug ingredients is large, the yield is low, and a large amount of ethanol is consumed at the same time, the energy consumption is large, the production process is complicated, the cycle is long, the efficiency is low, the cost is high, and the production safety is poor. It has a great impact on the environment, which can easily lead to unstable changes in the composition of the liquid medicine, and also makes a large number of polysaccharides with anti-tumor effects unused

The patent document with the application number 200410004443.4 discloses a preparation method of freeze-dried powder injection of traditional Chinese medicine for the treatment of tumors. It adopts the combination of alcohol extraction, macroporous adsorption resin impurity removal, water extraction and ultrafiltration. The process introduces medicinal materials The large amount of polysaccharides contained in the drug improves the curative effect, but it does not effectively intercept polysaccharides. This is because the molecular weight range of polysaccharides is very large, and the medicinal efficiency of polysaccharides with very small molecules is low. Polysaccharides with large molecular weights are not effective in injection It is easy to cause adverse reactions; at the same time, in the elution and purification step of macroporous resin, the selection of resin, the selection of eluent, and the control of elution speed have greatly affected the acquisition of active ingredients.

In addition, the conventional extraction method of medicinal materials is water extraction or alcohol extraction, but whether medicinal materials are suitable for water extraction, alcohol extraction or combination of alcohol and water is also a key point to be studied by pharmaceutical workers. The research on the extraction of a single medicinal material is not deep enough, which may easily lead to the problems of low extraction efficiency and high impurity content of the active ingredients of a single medicinal material in the preparation. Therefore, a feasible and effective preparation method for traditional Chinese medicine injection preparations is explored to improve the curative effect and reduce the adverse effects of traditional Chinese medicine injection preparations. Response is a problem for medical practitioners to solve

Images