Packaging for sodium bicarbonate injection and preparation thereof

Abstract

The invention discloses a package of sodium bicarbonate injection and a manufacturing method thereof. The package comprises a vessel (111, 41) that is made of gas barrier materials. The vessel contains the sodium bicarbonate injection (2) and is filled with carbon dioxide gas (3). The manufacturing method of the package is that the vessel is made of the gas barrier materials; the sodium bicarbonate injection (2) and the carbon dioxide gas (3) are loaded into the vessel; and a combination cover (12, 42) is hermetically connected with an interface or a bottle mouth. As the gas generated by drug liquid is sealed up in enclosed environment by a high gas barrier layer made of the gas barrier materials, and the drug liquid is in a relatively balanced state, thus ensuring the stability of the drug liquid. In addition, the plastic vessel is used for packaging of the liquid substances that can produce gas substances, such as the sodium bicarbonate injection, and the like, thus facilitating manufacturing, processing, transportation and storage.

Description

technical field [0001] The invention relates to the field of medical packaging, in particular to a packaging for sodium bicarbonate injection and a manufacturing method thereof. Background technique [0002] At present, in the field of pharmaceutical packaging, plastic packaging has been widely used for its good stability and low cost. [0003] However, some liquid medicines can only be packaged in glass bottles because glass bottles have high gas barrier properties. Taking the commonly used sodium bicarbonate injection as an example, because sodium bicarbonate injection is easily decomposed into sodium carbonate, carbon dioxide and water during storage, if this happens, the pH value of sodium bicarbonate injection will change, such as injection When it enters the human body, it will cause the pH value of the body fluid to be disturbed. The equation for the decomposition of aqueous sodium bicarbonate solution is: [0004] [0005] It can be seen from the above formula ...

AI Technical Summary

Problems solved by technology

[0006] If plastic bottles (bags) are used to pack sodium bicarbonate injection, because the plastic material (mainly polypropylene) gas barrier performance of existing plastic bags is not very good (especially during high temperature sterilization), so sodium bicarbonate aqueous solution The decomposed carbon dioxide gas will permeate out of the bag. When the carbon dioxide gas in the bottle (bag) is lost, the aqueous sodium bicarbonate solution in the bottle (bag) will decompose, resulting in a change in the pH value of the sodium bicarbonate injection.

[0007] Therefore, glass bottles can only be used at present, and plastic containers cannot be used as packaging materials for liquid substances such as sodium bicarbonate injection.

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