Abricycline molecular imprinting polymer membrane electrode and preparation and application thereof

A technology of polymer film and molecular imprinting, which is applied to the analysis of materials, material analysis by electromagnetic means, measurement devices, etc., to achieve the effect of low cost, short time consumption and easy operation

Inactive Publication Date: 2008-12-17
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compared with the widespread use of tetracycline, these...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1: Preparation of Tetracycline Molecularly Imprinted Polymer Membrane Electrode with Platinum Deposited Titanium Electrode as Electrode Substrate and Its Electrochemical Detection Application

[0027] Take 0.1g of tetracycline hydrochloride, 0.048mL of styrene, 3.53mL of ethylene glycol dimethacrylate (the molar ratio is 1:2:90), and 0.05g of azobisisobutyronitrile, mix and dissolve them in 10ml of methanol, The mixture was placed in an ultrasonic cleaner for ultrasonic dissolution and mixing to form a sol.

[0028] The commercially pure titanium sheet (purity > 99%) with a size of 20mm×30mm was polished with 350#, 500#, 800#, 1000# and 1200# emery paper in sequence, then ultrasonically cleaned in ethanol solution for 3 minutes, and then cleaned with Ultrasonic cleaning with deionized water for 20 minutes to thoroughly clean the titanium sheet. Platinum was electrodeposited in a three-electrode system, the deposition solution was 2g / L chloroplatinic acid soluti...

Embodiment 2

[0033] Example 2: Preparation of Tetracycline Molecularly Imprinted Polymer Membrane Electrode with Gold Deposited Titanium Electrode as Electrode Substrate and Its Electrochemical Detection Application

[0034] Take 0.2g of tetracycline hydrochloride, 0.167mL of styrene, 3.53mL of ethylene glycol dimethacrylate (the molar ratio is 2:7:90), and 0.06g of azobisisobutyronitrile, mix and dissolve them in 14ml of methanol, The mixture was placed in an ultrasonic cleaner for ultrasonic dissolution and mixing to form a sol.

[0035] After the commercially pure titanium sheet (purity>99%) that size is 20mm * 30mm is polished and cleaned by the process described in embodiment 1, gold is electrodeposited in 2g / L chloroauric acid solution, and this chloroauric acid solution contains 0.01mmol / L of hydrochloric acid solution, the deposition voltage is -0.30V (relative to the saturated calomel electrode), and the deposition time is 30 minutes. After the deposition, rinse with deionized w...

Embodiment 3

[0040] Example 3: Preparation of Tetracycline Molecularly Imprinted Polymer Membrane Electrode with Platinum Deposited Platinum Electrode as Electrode Substrate and Its Electrochemical Detection Application

[0041] Take 0.3g of tetracycline hydrochloride, 0.357mL of styrene, 3.53mL of ethylene glycol dimethacrylate (molar ratio is 3:15:90), and 0.06g of azobisisobutyronitrile, mix and dissolve them in 15ml of chloroform , put the mixture in an ultrasonic cleaner for ultrasonic dissolution and mixing to form a sol.

[0042] A platinum electrode (purity > 99%) with a size of 20mm × 30mm is 2 o 3 After the powder is ground, place it in an ethanol solution for ultrasonic cleaning for 3 minutes, and then use deionized water for ultrasonic cleaning for 20 minutes to thoroughly clean the platinum electrode. Platinum was electrodeposited by a three-electrode system, the deposition solution was 2g / L chloroplatinic acid solution, the chloroplatinic acid solution contained 0.01mmol / L ...

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PUM

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Abstract

The invention relates to a tetracycline molecular imprinted polymer and an electrochemical detection application in the electrode preparation by adopting the polymer. The tetracycline molecular imprinted polymer is composed of an electrode matrix and a tetracycline molecular imprinted polymer film which covers the electrode matrix and elutes the template molecules. The tetracycline molecular imprinted polymer film is prepared from the template molecules, functional monomer, a cross-linking agent, an initiating agent and a pore-forming agent by mixing, ultrasonic dissolving and polymerizng on the electrode matrix by the photopolymerization. The membrane electrode of the tetracycline molecular imprinted polymer is applicable in detecting tetracycline in the water body in the electrochemical method which adopts the membrane electrode as a working electrode and establishes a standard curve based on the correspondent relationship between the concentration of tetracycline and the current, so as to detect tetracycline. The detection method has the advantages of low cost, convenient operation and short detection time, and is applicable in the on-site rapid detection of the tetracycline residual quantity in the livestock farming sewage and the aquiculture sewage samples.

Description

technical field [0001] The invention relates to a tetracycline molecularly imprinted polymer, and the polymer is used to prepare an electrode and its application in electrochemical detection. Background technique [0002] Tetracycline (TC for short) molecular formula is C 22 h 26 N 2 o 7 , with a molecular weight of 430.45, belongs to a broad-spectrum antibacterial drug in the tetracycline class. It is an amphoteric substance that can react with alkali or acid to form a salt. Usually easy to degrade in alkaline aqueous solution, relatively stable in acidic aqueous solution. In my country, the irrational use of antibiotics in the pharmaceutical industry and the extensive use of antibiotics in animal husbandry and aquaculture are very common, resulting in a very high level of antibiotic residues in animals, manure, and water and soil. As environmental exogenous chemicals, these residual antibiotics have extensive and far-reaching impacts on environmental organisms and eco...

Claims

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Application Information

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IPC IPC(8): G01N27/333
Inventor 赵慧敏王红涛全燮陈硕张耀斌
Owner DALIAN UNIV OF TECH
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