Method to assess breast cancer risk

A breast cancer, risk-related technology, applied in the direction of biochemical equipment and methods, microbiological determination/inspection, instruments, etc., can solve the fear of pain, recommend screening guidance, education, limited availability, factors that limit the wide application of mammography, etc. question

Inactive Publication Date: 2009-01-14
CHILDRENS MEDICAL CENT CORP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Cost, fear of pain, and lack of education about recommended screening guidelines are also factors that limit widespread use of mammography 50，51
Mammography examinations require highly skilled professionals and the purchase and placement of large and expensive equipment, as well as maintenance work and quality assurance costs
All of these constraints can limit its availability, especially for disadvantaged women

Method used

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  • Method to assess breast cancer risk
  • Method to assess breast cancer risk
  • Method to assess breast cancer risk

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0160] Example 1: Urinary Biomarkers Provide a New Non-Invasive Method for Assessing Breast Cancer Risk

[0161] method

[0162] research group

[0163] Invited subjects to participate in surgical clinics, radiation oncology clinics at the Beth Israel Deaconess Medical Center, the Mount Auburn Hospital, and the Dana Farber Cancer Institute and medical oncology clinical research. Age-matched normal healthy controls were from women who routinely came to Brigham and Women's Hospital for screening mammograms and who reported no chronic health problems, no breast disease, had normal mammograms and were not on medication . All participants provided a detailed medical history form when donating urine. Pregnant and lactating women were excluded from the study. Calculation of Risk Score Using Improved Gail Model 66，67 .

[0164] Urine Sample Collection and Processing

[0165] collect urine as previously described 4 . Samples were collected in sterile containers and immedi...

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Abstract

We show that urinary metalloproteinases (MMP's) (e.g. MMP 9) and a disintegrin and metalloprotease 12 (ADAM 12) are significantly elevated in women at high risk for developing breast cancer and that monitoring for the absence or presence of both MMP 9 and ADAM 12 represents a new means for breast cancer risk assessment. In addition, we show that levels of MMP 9 and ADAM 12 serve as independent predictors of breast cancer risk. Furthermore, we have determined that elevated levels of urinary ADAM 12 predict an increased risk for breast cancer in subjects predicted not to be at risk for breast cancer by the Gail 5 -year risk model<66'67>. Accordingly, methods for assessing breast cancer risk and methods for directing medical care are provided.

Description

[0001] cross reference [0002] This application claims the benefit of US Provisional Application No. 60 / 737,281, filed November 16, 2005, and US Provisional Application No. 60 / 846,456, filed September 22, 2006, under 35 U.S.C. § 119(e). [0003] governmental support [0004] This invention was supported in part by National Institutes of Health (NIH) Grant No. PO1CA45548. The US Government has certain rights in this invention. Background technique [0005] Breast cancer is the most common cancer in women and the second leading cause of cancer death in women today. The lifetime probability of invasive breast cancer in women is about one in seven (13.4%). Breast cancer is one of the most commonly diagnosed cancers worldwide and is the most prevalent cancer in the world 1 . The American Cancer Society estimates that in 2005 approximately 211,240 American women will be diagnosed with invasive breast cancer and 40,410 women will die from the disease 2 . Invasive breast cance...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574C12Q1/37
Inventor 玛莎·A·莫塞斯苏珊·波里斯大卫·茹拉科夫斯基
Owner CHILDRENS MEDICAL CENT CORP
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