Contact lens nursing liquid or moisture retention eye drop containing polyethylene glycol hydrogenated castor oil

A technology of polyoxyethylene hydrogenated castor and hydrogenated castor oil, which is applied in chemistry and other fields, can solve the problems of unsatisfactory molecular chain stretching, complicated preparation process, and large eye irritation, and achieve good sensory properties, uniform solution properties, The effect of low production cost

Inactive Publication Date: 2009-03-25
GUANGZHOU BAOSHINING OPTICAL PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although glycerin has strong moisturizing properties, it is very irritating to the eyes; cellulose, polyvinyl alcohol and polyvinyl pyrrolidone, because of their original properties as solid polymers, are all water-soluble, but the degree of stretching of their molecular chains in aqueous solution is still not very good. Ideal; as a biological macromolecule, although hyaluronic acid has good biocompatibility, its preparation process is complicated and the cost is high, which to a certain extent inhibits its wide application
[0005] There has not been any report about the application of polyoxyethylene hydrogenated castor oil as a moisturizing lubricant in the care solution for contact lenses

Method used

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  • Contact lens nursing liquid or moisture retention eye drop containing polyethylene glycol hydrogenated castor oil
  • Contact lens nursing liquid or moisture retention eye drop containing polyethylene glycol hydrogenated castor oil
  • Contact lens nursing liquid or moisture retention eye drop containing polyethylene glycol hydrogenated castor oil

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Embodiment 1: the formula of contact lens care solution is as follows, unit (g / L):

[0046] Polyoxyl-40 Hydrogenated Castor Oil 1.0

[0047] Polyvinylpyrrolidone 3.0

[0048] Methylcellulose 0.5

[0049] Ethylene oxide-propylene oxide copolymer 20.0

[0050] Sodium citrate 1.0

[0051] Sodium dihydrogen phosphate 1.0

[0052] Disodium hydrogen phosphate 6.0

[0053] Sodium chloride 8.0

[0054] Polyhexamethylene biguanide hydrochloride 0.0018

[0055] The rest is pure water.

Embodiment 2

[0056] Embodiment 2: the formula of contact lens care solution is as follows, unit (g / L):

[0057] Polyoxyethylene-40 Hydrogenated Castor Oil 20.0

[0058] Hyaluronic Acid 0.1

[0059] Hydroxypropyl methylcellulose 0.4

[0060] Polyoxyethylene sorbitan 10.0

[0061] Disodium EDTA 1.5

[0062] Sodium dihydrogen phosphate 1.0

[0063] Disodium hydrogen phosphate 6.0

[0064] Sodium chloride 8.0

[0065] Polyhexamethylene biguanide hydrochloride 0.002

[0066] The rest is pure water.

Embodiment 3

[0067] Embodiment 3: the formula of contact lens care solution is as follows, unit (g / L):

[0068] Polyoxyethylene-40 hydrogenated castor oil 40.0

[0069] Polyethylene glycol 2.0

[0070] Hydroxypropyl methylcellulose 0.8

[0071] Ethylene oxide-propylene oxide copolymer 20.0

[0072] Disodium EDTA 1.5

[0073] Sodium dihydrogen phosphate 1.0

[0074] Disodium hydrogen phosphate 6.0

[0075] Sodium chloride 8.0

[0076] Polyhexamethylene biguanide hydrochloride 0.0018

[0077] The rest is pure water.

[0078] The polyoxyethylene hydrogenated castor oil that is added to the polyoxyethylene hydrogenated castor oil in the formula of embodiment 1~3 is the polyoxyethylene-40 hydrogenated castor oil that polyoxyethylene chain number is 40~45, and its molecular weight is 2.8 x 10 3 ~3.1 x 10 3 . Polyoxyethylene-40 hydrogenated castor oil is a white pasty substance or a transparent colorless viscous liquid at room temperature, and its aqueous solution will change from clear...

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Abstract

The invention discloses contact lens nursing liquid or moisture eye moistening liquid containing polyoxyethylene hydrogen castor oil. The contact lens nursing liquid is composed of the polyoxyethylene hydrogen castor oil, pH regulator, osmotic pressure regulator, metal complex, surface active agent, thickening agent, bactericide and water, and the contact lens lubricating moist liquid is composed of the polyoxyethylene hydrogen castor oil, the pH regulator, the osmotic pressure regulator, the metal complex, the thickening agent, preservative and water. The polyoxyethylene hydrogen castor oil selected by the invention has a plurality of branched chains and good lubricating performance; and the existence of the polyoxyethylene end enable the product to have good moist performance. The polyoxyethylene hydrogen castor oil is viscous liquid, is easily dissolved in water, has even solution performance, and does not have the condition that fine granules or macromolecules curl and enwind in aqueous solution because solid macromolecule raw materials can not completely dissolved to further cause the problem that eyes feel uncomfortable. The obtained product is achromatous and flavourless, and has good user reception, low production cost, and wide source of the main material of the castor oil.

Description

technical field [0001] The invention relates to the application of polyoxyethylene hydrogenated castor oil as a moisturizing lubricant in a care solution for contact lenses, in particular to a contact lens care solution containing polyoxyethylene hydrogenated castor oil and a contact lens containing polyoxyethylene hydrogenated castor oil for moisturizing eyes liquid. Background technique [0002] Polyoxyethylene hydrogenated castor oil is a branched saturated ester obtained from natural castor oil through glycerol esterification, low molecular weight polyethylene glycol etherification, and hydrogenation. Castor oil is one of the top ten oils in the world. Its derivative polyoxyethylene hydrogenated castor oil is a viscous white waxy substance or a transparent colorless liquid at room temperature. Polyoxyethylene hydrogenated castor oil has good water solubility, and the solubility in water is above 490.0 (g / L) (23°C); the aqueous solution is neutral; it is generally consid...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L12/14
Inventor 宋伟林冬青谢春兰
Owner GUANGZHOU BAOSHINING OPTICAL PROD
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