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Plant lactobacillus M1-UVs29 and uses thereof

A technology of Lactobacillus plantarum and m1-uvs29, applied in the field of microorganisms, can solve the problems of unsatisfactory curative effect, and achieve the effects of lowering cholesterol content, less toxic and side effects, and superior safety.

Inactive Publication Date: 2009-04-08
于长青
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The latest research shows that microbial flora has been paid more and more attention due to its superior safety and low toxic and side effects. The research of microbial ecology experts on lactic acid bacteria, bifidobacteria and enterococci in probiotics has shown that it has a certain relationship with the degradation of cholesterol. However, the curative effect of probiotics in the treatment of CVD reported at present is not yet ideal, and screening the best strains becomes the key to the treatment of CVD with probiotics

Method used

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  • Plant lactobacillus M1-UVs29 and uses thereof
  • Plant lactobacillus M1-UVs29 and uses thereof
  • Plant lactobacillus M1-UVs29 and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Isolation, identification and biological characteristics of Lactobacillus plantarum M1-UVs29

[0034] 1. Materials

[0035] 1.1 Samples: fermented meat products from various sources, such as bacon, sausage, air-dried sausage, Xuanwei ham, etc.

[0036] 1.2 Reagents:

[0037] Lactic acid standard chromatographically pure American Sigma company

[0038] Crystal violet Analytical grade Tianjin Xinghua Chemical Reagent Factory

[0039] Safranin Analytical grade Tianjin Xinghua Chemical Reagent Factory

[0040] Iodine Analytical grade Tianjin Xinghua Chemical Reagent Factory

[0041] Potassium iodide Analytical grade Tianjin Xinghua Chemical Reagent Factory

[0042] Tween 80 analytically pure Tianjin Bodi Chemical Co., Ltd.

[0043] Cysteine ​​Analytical Pure Guangdong Biotech Biological Co., Ltd.

[0044] Lead acetate analytically pure Tianjin Xinghua Chemical Reagent Factory

[0045] Cholesterol chromatographically pure American Sigma company

[0046] Bile salt an...

Embodiment 2

[0142] Observation of curative effect of Lactobacillus plantarum M1-UVs29 gavage on mice with hyperlipidemia. The animal models were divided into normal control group (NC), induced high-fat control group (HFC), low-dose group (LD), middle-dose group (MD) and high-dose group (HD) respectively administered with Lactobacillus plantarum M1-UVs29. Gastric feeding, observe the body weight and pathological changes of the mice in each group. The results show that: Lactobacillus plantarum M1-UVs29 can reduce the blood lipid level of experimental animals, alleviate clinical symptoms, and can effectively prevent and treat various cardiovascular diseases such as coronary heart disease, atherosclerosis, and hyperlipidemia caused by hyperlipidemia.

[0143] 1. Experimental materials and methods:

[0144] 1. Experimental animal grouping and feeding

[0145] Sixty male and female Wistar rats, 6.8 weeks old and weighing 180-220 g, were selected from Changchun Biological Products Company and ...

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Abstract

The invention discloses a Lactobacillus plantarum M1-UVs29 with an accession number of CGMCC No.2591. The Lactobacillus plantarum M1-UVs29 can be isolated from fermented meat products of various resources, such as preserved ham, sausage, salami, Xuanwei ham and the like, and is obtained after induced mutation and optimization. The Lactobacillus plantarum M1-UVs29 is a new strain of the induced mutation and isolation and has superior safety and minimal toxic and side effects, and can relieve classical clinical symptoms of coronary heart diseases, atherosclerosis, hyperlipemia and the like and treat cardiovascular diseases of various coronary heart diseases, atherosclerosis, hyperlipemia and the like incurred by hyperlipemia in a safe and effective way. The Lactobacillus plantarum M1-UVs29 is applied to the production of beverages, and health products of dairy products, fermented milk, acidsoy milk and the like and food additives. The obtained products of beverages, health products and food additives, containing the fermented Lactobacillus plantarum M1-UVs29 or metabolins, cell debris or secretions thereof, can effectively degrade cholesterol self-cumulated by human bodies and self-contained by food.

Description

1. Technical field [0001] The invention relates to the technical field of microbes, in particular to a new strain of Lactobacillus plantarum screened by mutagenesis and the application of the strain. 2. Background technology [0002] The main pathological basis of cardiovascular and cerebrovascular disease (cerebrovascular disorder; CVD) is coronary heart disease (coronary heart disease, CHD), atherosclerosis (atherosclerosis, AS), hyperlipidemia (hyperlipoidemia,), etc., control blood lipid The level of serum cholesterol is an important link to prevent and reduce CHD, AS and HL and prevent cardiovascular and cerebrovascular diseases, and high serum cholesterol is an important factor in inducing these diseases, and the cholesterol in human diet is also positively correlated with the cholesterol in blood. The pathogenesis of cardiovascular and cerebrovascular diseases is characterized by complex, multi-environment, and multi-factor interactions, which are affected by factors ...

Claims

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Application Information

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IPC IPC(8): C12N1/20A61K35/74A23C9/12A23L1/29A23L1/30A61P9/10A61P3/06C12R1/25A23L33/135A61K35/747
Inventor 于长青张丽娜王颖姚笛王长远
Owner 于长青
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