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Quality control method of aristolochic acid A in Asarum medicinal materials and repellent-antalgesic tincture

A quality control method and aristolochic acid technology, applied in the field of medicine, can solve the problems of human nephrotoxicity and lack of inclusion, and achieve the effect of high sensitivity and satisfying quality control.

Active Publication Date: 2009-06-17
广西壮族自治区花红药业集团股份公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology provides an improved way for controlling the purity level of certain chemicals used during manufacturing processes. It achieves this through specific methods with good precision and reliable results over time.

Problems solved by technology

This patented technical problem addressed by this patents relates to controlling the amount or concentration (the ratio) at which certain chemicals are added during manufacturing processes used to produce an antispasmodiecake without causing harmful effects such as inflammation caused by these compounds.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Asarum medicinal materials were purchased from Liuzhou Medicinal Materials Station

[0052] The specific operation of Asarum medicinal material inspection is as follows:

[0053] 1. Chromatographic conditions:

[0054] Chromatographic column: silica gel column bonded with octadecylsilane.

[0055] The composition of the mobile phase is: an aqueous solution containing 1ml / L phosphoric acid and 0.05mol / L sodium dihydrogen phosphate, acetonitrile, and tetrahydrofuran; the ratio of these three solutions is 66:26:8.

[0056] Flow rate: 1ml / min.

[0057] Column temperature: 25°C.

[0058] Detection wavelength: 319nm.

[0059] 2. Preparation of reference solution: Accurately weigh an appropriate amount of aristolochic acid A, add methanol to make a solution containing 500ng of aristolochic acid A per milliliter.

[0060] 3. Preparation of the test solution: Take 2 g of Herba Asarum powder, accurately weigh, add 50 ml of 5% ammonia solution, weigh, ultrasonically treat for 3...

Embodiment 2

[0064] Test product: using anti-tumor and pain-relieving tincture, a commercially available product, produced by Huahong Pharmaceutical Co., Ltd. of Guangxi Zhuang Autonomous Region, batch number: 20070705

[0065] The specific operation of the test for reducing swelling and relieving pain tincture is as follows:

[0066] 1. Chromatographic conditions:

[0067] Chromatographic column: silica gel column bonded with octadecylsilane.

[0068] The composition of the mobile phase is: an aqueous solution containing 1ml / L phosphoric acid and 0.05mol / L sodium dihydrogen phosphate, acetonitrile, and tetrahydrofuran; the ratio of these three solutions is 65:26:8.

[0069] Flow rate: 0.8ml / min.

[0070] Column temperature: 25°C.

[0071] Detection wavelength: 319nm.

[0072] 2. Preparation of reference solution: Accurately weigh an appropriate amount of aristolochic acid A, add methanol to make a solution containing 500ng of aristolochic acid A per milliliter.

[0073] 3. Preparatio...

Embodiment 3

[0077] Test product: using anti-tumor and pain-relieving tincture, a commercially available product, produced by Huahong Pharmaceutical Co., Ltd. of Guangxi Zhuang Autonomous Region, batch number: 20070801

[0078] The specific operation of the test for reducing swelling and relieving pain tincture is as follows:

[0079] 1. Chromatographic conditions:

[0080] Chromatographic column: silica gel column bonded with octadecylsilane.

[0081] The composition of the mobile phase is: an aqueous solution containing 1ml / L phosphoric acid and 0.05mol / L sodium dihydrogen phosphate, acetonitrile, and tetrahydrofuran; the ratio of these three solutions is 66:26:8.

[0082] Flow rate: 1ml / min.

[0083] Column temperature: 40°C.

[0084] Detection wavelength: 319nm.

[0085] 2. Preparation of the reference solution: Accurately weigh an appropriate amount of aristolochic acid A, add methanol to make a solution containing 500 ng of aristolochic acid A per milliliter, and obtain.

[0086...

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Abstract

A quality control method of asarum medicinal materials and swell-removing and ache-relieving tincture is to control content of aristolochic acid A in asarum medicinal materials and so as to guarantee that content of aristolochic acid A in asarum medicinal material which is one raw material of the swell-removing and ache-relieving tincture is not over standard and guarantee that content of aristolochic acid A in the swell-removing and ache-relieving tincture meets security requirement of products. The method provided by the invention solves detection problem of micro-aristolochic acid A and establishes a reliable quality control method of aristolochic acid A. In view of operation, the method provided by the invention is simple and feasible, accurate and reliable, has high precision and high use value.

Description

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Claims

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Application Information

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Owner 广西壮族自治区花红药业集团股份公司
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