Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Terpyridyl complex two-photon material with cell development and preparation

A terpyridine, cell imaging technology, applied in the direction of zinc organic compounds, preparations for in vivo tests, pharmaceutical formulations, etc., to achieve the effects of easy availability of raw materials, high yield and strong penetration

Inactive Publication Date: 2009-07-08
ANHUI UNIVERSITY
View PDF0 Cites 18 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] Full Text - Terpyridine Zn(II)S 2 Complex two-photon absorbing materials No relevant literature

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Terpyridyl complex two-photon material with cell development and preparation
  • Terpyridyl complex two-photon material with cell development and preparation
  • Terpyridyl complex two-photon material with cell development and preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0039] 1. Preparation of terpyridine derivatives

[0040] The synthesis of terpyridine derivatives is based on the Wittg reaction between phosphonium salts and aldehydes.

[0041] Firstly, according to the literature (Bull.Chem.Soc.Jpn.2007, 80, 986-993), the phosphine salt of terpyridyl group is prepared, and the synthetic route is as follows:

[0042]

[0043] Then, according to the Wittg reaction, the phosphonium salt, R-CHO and potassium tert-butoxide were thoroughly ground in a mortar until viscous, and the 2 Cl 2 The target product was obtained by dissolving, washing with water, drying, filtering, concentrating and column separation.

[0044] Taking R-CHO as N-hexylcarbazole formaldehyde as an example, the synthetic route is as follows:

[0045]

[0046] 2. Synthesis of the target product

[0047] Take the terpyridine derivative (marked as L) when R is N-hexylcarbazole as the auxiliary ligand as an example. at 20cm 3 19.4mg (0.2mmol) of ZnS nanocrystals, 115....

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention disclose a two photon absorption material capable of imaging alive cells, which is a terpyridine derivative Zn(II)S2 complex. The complex is a two photon absorption material having a property of two-photon fluorescence imaging of alive tissue cells, has the characteristics of large absorption area, low excitation energy, large wavelength, high penetrability, less light injuries, non-toxicity and the like and is suitable to be used for detecting alive cells.

Description

1. Technical field: [0001] The invention relates to a two-photon absorption material and a preparation method thereof, in particular to a two-photon absorption material with the function of developing living tissue cells and a synthesis method thereof. 2. Background technology [0002] In recent years, with the discovery of two-photon absorbing materials, two-photon fluorescence technology has made a major breakthrough in its application. Since the two-photon technology uses long-wavelength excitation (near-infrared), it has the characteristics of low excitation energy, long wavelength, strong penetration, and small photodamage. It has attractive application prospects in medical diagnosis and fluorescence microscopy imaging. In 2004, O'Halloran (J.Am.Chem.Soc., 2004, 126, 712-713) reported the use of Zn(II) ion-centered complex two-photon fluorescence microscopy in the detection of living tissue cells The application of this method has successfully solved the disadvantage o...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07F3/06C07D213/89A61K49/00
Inventor 田玉鹏高远浩吴杰颖张胜义周虹屏杨家祥金葆康李胜利薛照明马文张骞
Owner ANHUI UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com