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Soft-capsule coating method

A soft capsule and coating technology, applied in the direction of oil/fat/wax inactive ingredients, etc., can solve the problems of reducing the dissolution rate in vitro and accelerating the change of gelatin.

Active Publication Date: 2012-01-11
SICHUAN KELUN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have found that strong ultraviolet or visible light irradiation will accelerate the change of gelatin, resulting in a decrease in the dissolution rate in vitro, such as high humidity while the light is on, and the gelatin capsule contains red dye, the effect is particularly significant

Method used

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Experimental program
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Effect test

Embodiment 1

[0021] Embodiment 1: the preparation of polyene phosphatidylcholine soft capsule

[0022] Prescription: polyene phosphatidylcholine 228g soybean oil 222g

[0023] Rubber prescription: gelatin 10kg, glycerin 4kg, purified water 10kg, ethyl p-hydroxybenzoate 50g

[0024] Coating material prescription: hydroxypropyl methylcellulose 25g Tween-80 15ml, titanium dioxide 10g, talcum powder 20g, 2% chocolate brown solution 8ml, castor oil 35ml, add propylene glycol, 50% ethanol to make 5000ml coating liquid .

[0025] Preparation method: (1) Chemical glue: Weigh glycerin, purified water and ethyl p-hydroxybenzoate according to the prescription amount, put them in a chemical glue tank, stir, heat in a water bath to 50°C-60°C, stir and add gelatin, continue to stir, Water bath.

[0026] (2) Weigh polyene phosphatidylcholine and soybean oil according to the prescription, grind for 40 minutes, and make 1000 soft capsules, to obtain.

[0027] (3) Weigh hydroxypropyl methylcellulose, Tw...

Embodiment 2

[0028] Embodiment 2: the preparation of Danshu soft capsule

[0029] Prescription: peppermint oil 100g soybean oil 200g

[0030] Rubber prescription: gelatin 10kg, glycerin 4kg, purified water 10kg, ethyl p-hydroxybenzoate 50g

[0031] Coating material prescription: carboxymethyl cellulose 5g, methyl acrylate polymer 50g, titanium dioxide 15g, talcum powder 7.5g, 2% chocolate brown solution 15ml, castor oil 25ml, add ethoxyethanol, methanol to make 5000ml

[0032] Preparation method: (1) Chemical glue: Weigh glycerin, purified water and ethyl p-hydroxybenzoate according to the prescription amount, put them in a chemical glue tank, stir, heat in a water bath to 50°C-60°C, stir and add gelatin, continue to stir, Water bath.

[0033] (2) Weigh peppermint oil and soybean oil according to the prescription, grind for 40 minutes, and make 1000 soft capsules.

[0034] (3) Weigh carboxymethyl cellulose, methyl acrylate polymer, titanium dioxide, talcum powder, food coloring, castor ...

Embodiment 3

[0035] Embodiment 3: the preparation of Jingangteng Soft Capsule

[0036] Prescription: King Kong vine 10000g soybean oil appropriate amount

[0037] Rubber prescription: gelatin 10kg, glycerin 4kg, purified water 10kg, ethyl p-hydroxybenzoate 50g

[0038] Coating material prescription: methyl methacrylate polymer 75g, methyl cellulose 75g, titanium dioxide 25g, talcum powder 25g, 2% chocolate brown solution 25ml, castor oil 40ml, Tween-80 25ml, add 80% ethanol to make 5000ml

[0039] Preparation method: (1) Chemical glue: Weigh glycerin, purified water and ethyl p-hydroxybenzoate according to the prescription amount, put them in a chemical glue tank, stir, heat in a water bath to 50°C-60°C, stir and add gelatin, continue to stir, Water bath.

[0040] (2) Take King Kong vine, add 10 times the amount of water, decoct twice, 2 hours each time, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.15 (50°C), add ethanol to make the solution cont...

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Abstract

The invention relates to a method for coating a soft capsule. The method comprises the following steps: preparing a coating liquid which comprises 25 to 150 weight portions of hydroxypropyl methylcellulose, 8.5 to 25 volume portions of Tween-80, 7.5 to 25 weight portions of titanium dioxide, 7.5 to 25 weight portions of talcum powder, 7.5 to 25 volume portions of 2 percent chocolate brown solution, and 15 to 40 volume portions of caster oil; adding 10 to 90 percent ethanol into the coating liquid to prepare a coating liquid of 5,000 volume portions; and coating the soft capsule by the coating liquid, controlling flow velocity of a coating material at 20 to 80 liter / hour, air inlet temperature at 30 to 90 DEG C, and drying the soft capsule at a temperature of between 25 and 40 DEG C and relative humidity of between 20 and 60 percent to produce the coated soft capsule. The method can form a protective screen outside glutin so as to prevent the glutin from directly contacting with moisture, oxygen and ultraviolet. Compared with a common soft capsule, the product has obviously slowed aging speed, is quickly disintegrated, and effectively ensures medicine quality.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to a soft capsule coating method. Background technique [0002] At present, soft capsule preparations are developing rapidly. my country already has 369 domestically produced drugs, 610 varieties accepted for registration, and a total of 979 varieties. Compared with other dosage forms, soft capsules have the characteristics of high bioavailability, good sealing, good drug stability, accurate content, and beautiful appearance. The water-insoluble or water-soluble drugs, as well as the drugs with bad taste and smell, can increase stability, improve bioavailability and taste masking. [0003] Most of the existing soft capsules use gelatin as the capsule material and glycerin as the plasticizer. Due to the properties of gelatin itself and the high permeability of glycerin, soft capsules also have some stability problems, such as disintegration during storage. Phenomena such as material migrati...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/44
Inventor 胡思玉谭兴根罗琴李转花余启波张德奎王利春梁隆程志鹏
Owner SICHUAN KELUN PHARMA CO LTD