Skin-care cosmetic dispelling freckles and containing nonane diacid

A skin care cosmetic, azelaic acid technology, applied in the field of freckle skin care cosmetics, can solve the problems of affecting the penetration and absorption of azelaic acid, affecting the beauty of the skin, and being difficult to add, so as to achieve high effective content, eliminate melanin and acne, and smooth skin and whitening effect

Inactive Publication Date: 2009-09-09
NINGBO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since azelaic acid is insoluble in water and oil, it is difficult to add it to various freckle-removing skin care cosmetics. In order to make azelaic acid compatible with skin care cosmetics, azelaic acid has been modified to make azelaic acid diglycine Potassium salt solution, although this solves the solubility problem of azelaic acid in water, it cannot be used directly as a cosmetic, otherwise when the water on the skin evaporates, the potassium salt of diglycine azelaic acid will precipitate on the skin surface, Make the skin appear powdery white, which affects the beauty of the skin, and also affects the penetration and absorption of azelaic acid
Therefore, azelaic acid diglycine potassium salt can only be used as an additive in the cosmetic base, but within the range of its addition, the content of its functional component azelaic acid can only reach 1.5%

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] The preparation of chitosan azelaic acid salt is to add 10g of chitosan with a deacetylation degree of not less than 50% to deionized water, stir, put it into a water bath at about 50°C and add 5g of azelaic acid while stirring. Acid, stirring continuously, until the reaction is completed, a uniform chitosan azelate sol is generated, and the sol is dried to obtain solid chitosan azelate.

Embodiment 2

[0016] A freckle-removing skin cream containing azelaic acid, first dissolving 5 g of chitosan azelaic acid polymer and 0.8 g of vitamin E acetate in water, stirring and dissolving to make a water phase for subsequent use, then adding 4 g of cetyl alcohol, Mix 4g of petroleum jelly, 1g of glycerin stearate and 30g of polyoxyethylene cetyl ether, heat them to 70°C to fully melt the oil phase for noodle making, then mix the water phase with the oil phase, and add appropriate amount of essence and preservatives , stirring and making it emulsified, cooled to room temperature after emulsification, and aging for 24 hours to obtain a freckle-removing skin cream containing azelaic acid with a weight of 100g.

Embodiment 3

[0018] A freckle-removing skin cream containing azelaic acid is basically the same as in Example 1, except that the water phase also contains 2g of vitamin C and 4g of titanium dioxide.

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PUM

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Abstract

The invention discloses a skin-care cosmetic dispelling freckles and containing nonane diacid, comprising an oil phase and an aqueous phase. The aqueous phase contains chitosan azelate which is 2.8-8.2% of the total weight of the skin-care cosmetic dispelling freckles; the chitosan azelate is obtained after reaction between azelaic acid and chitosan according to the mass ratio of 1:1-2 at the temperature not higher than 70 DEG C; the deacetylation in the molecule of the chitosan is not lower than 50%. The skin-care cosmetic has relatively high effective content of the azelaic acid and has the advantages of antibiosis, freckles dispelling, moisture preserving, anti-crease, anti-comedo and the like; in addition, the skin has good texture after the skin-care cosmetic dispelling freckles and containing nonane diacid is used. The invention has no adverse side effects and provides a new skin-care cosmetic dispelling freckles for patients.

Description

technical field [0001] The invention relates to a freckle-removing skin-care cosmetic, in particular to a freckle-removing skin-care cosmetic containing azelaic acid. Background technique [0002] Freckle-removing skin care cosmetics are used to eliminate human spots, chloasma and acne. Freckle-removing skin care cosmetics contain oil phase and water phase ingredients. The oil phase is generally used as the matrix, and the water phase is used as the curative ingredient. The current components of the water phase include pure Chinese herbal medicine compound mixture, Chinese medicine extract preparation, mixture of Chinese medicine extract and chemical ingredients and For chemical composition preparations, some water phases contain mercury chemical components for whitening effect, and some water phases contain hormone chemical components for freckle removal and acne removal, so the freckle skin care cosmetics will bring adverse side effects to patients. [0003] Azelaic acid ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/73A61K8/92A61K8/67A61K8/29A61K8/362A61Q19/00A61Q19/08
Inventor 刘必谦周湘池刘凌颜昌威谭慧赵洲
Owner NINGBO UNIV
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