Composite of wall-breaking lucidum spore powder and cyclodextrin and preparation method thereof

A technology of broken Ganoderma lucidum spore powder and cyclodextrin is applied in the directions of non-active ingredients of polymer compounds, drug combinations, medical preparations containing active ingredients, etc. Absorption and utilization effect, contamination of the quality of subsequent products, etc., to achieve the effect of being conducive to absorption and utilization, solving easy oxidative deterioration, and strong hygienic stability

Inactive Publication Date: 2012-12-26
NANJING NORMAL UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The oily component overflowed after the Ganoderma lucidum spore powder is broken increases the viscosity of the product, and is widely adsorbed on mechanical equipment and operating equipment during subsequent processing, making it difficult to clean. The product causes a decline in the quality of the prepared product; the oily broken wall Ganoderma lucidum spore powder is very easy to agglomerate and has poor fluidity, which not only affects the preparation process, increases the difficulty of preparing various dosage forms, and affects the uniformity and stability of product quality
In addition, the oily component of the broken Ganoderma lucidum spore powder is poorly soluble in water and has poor dispersibility, thus reducing the absorption and utilization effect of the preparation product

Method used

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  • Composite of wall-breaking lucidum spore powder and cyclodextrin and preparation method thereof
  • Composite of wall-breaking lucidum spore powder and cyclodextrin and preparation method thereof
  • Composite of wall-breaking lucidum spore powder and cyclodextrin and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Example 1: Mix 240 grams of broken Ganoderma lucidum spore powder with 240 grams of β-cyclodextrin, add 500 milliliters of water and mix evenly, stir and grind for 1 hour, place it in a 50°C oven for 10 hours under reduced pressure after grinding, pulverize, pass Sieve to obtain about 480 grams of tan powdery solid clathrate.

Embodiment 2

[0053] Example 2 is basically the same as Example 1, but adding 300 grams of broken Ganoderma lucidum spore powder and mixing with 180 grams of β-cyclodextrin to prepare clathrates.

[0054] The obtained solid clathrate was added with the following auxiliary materials: 60 grams of microcrystalline cellulose, 39 grams of starch, 18 grams of sodium starch glycolate, and 3 grams of magnesium stearate; Mix the clathrate, mix thoroughly, moisten the soft material with 70% ethanol, pass through a 14-mesh sieve to granulate, dry at 50°C for 2 hours, add another 1 / 3 amount of auxiliary materials after granulation, mix well and then compress into tablets Get 1000 ganoderma spore powder sheet products (the broken ganoderma spore powder content: 300 mg / sheet).

Embodiment 3

[0055] Example 3, basically the same as Example 1, but adding 320 grams of broken Ganoderma lucidum spore powder and 160 grams of hydroxypropyl-β-cyclodextrin to prepare clathrates, mixed with auxiliary materials, granulated, and filled to obtain about 2130 capsules (Cracked Ganoderma lucidum spore powder content: 150mg / capsule).

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Abstract

The invention relates to a composite of wall-breaking lucidum spore powder and cyclodextrin and a preparation method thereof. The composite consists of 1 part of lucidum spore powder and 0.5 to 3 parts of cyclodextrin based on weight part. In the optimum scheme, the mass ratio of the wall-breaking lucidum spore powder and the cyclodextrin is 1:1.0-1.5. The preparation method comprises the steps of weighting one part of fresh wall-breaking lucidum spore powder and 0.5 to 20 parts of beta cyclodextrin to mix evenly, adding purified water 1 to 3 time of solids, grinding completely for 1 to 3 hours to obtain a pasty product, placing the pasty product in a drying box for decompression drying at a temperature lower than 60 DEG C, grinding and sieving to obtain solid powdery inclusion compound. The powdery inclusion compound can be pelletized by drying process or by adding auxiliary materials, or be directly packaged into capsule or press tablet. The composite is lucidum spore powder solid with strong stability, high solubility, favorable flowability and easy production, or can be prepared into preparation with multiple performances by general operation of solid preparation.

Description

technical field [0001] The invention relates to a composition of broken ganoderma lucidum spore powder and cyclodextrin and a preparation method thereof. Background technique [0002] Ganoderma lucidum is a fungus belonging to the Basidiomycetes Polyporaceae family and is a good medicinal fungus. Li Shizhen of the Ming Dynasty believed in Compendium of Materia Medica that Ganoderma lucidum has the functions of clearing heat and detoxifying, strengthening the heart, nourishing the kidney and protecting the liver, nourishing and strengthening the body, strengthening the body, beautifying the skin, calming the nerves and replenishing essence. Ganoderma lucidium spores are extremely tiny spores ejected from the cap of Ganoderma lucidum during the growth and maturity stage of the fruiting body of Ganoderma lucidum. It condenses all the essence of Ganoderma lucidum and contains all the genetically active substances of Ganoderma lucidum. It has a wide range of pharmacological acti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/074A61K47/40A61P35/00A61P37/04A61P39/02A61P3/10A61P1/16A61P17/00A61P39/06A61P25/20A61P11/06A61P11/10A61P11/14
Inventor 任勇安翠翠吴玲裴会娜
Owner NANJING NORMAL UNIVERSITY
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