Antineoplastic medicine composition and application thereof

Abstract

The invention provides a medicine composition with a compound 1 (5, 17, 20-trivinyl-ingenane-3-angelate) and a compound 2 (5, 20-diacetyl-ingenane-3-angelate) shown in formula (1) as active ingredients and an application thereof in preparing medicine for treating or preventing and controlling tumor diseases; when R is equal to OAc, the compound 1 is 5, 17, 20-trivinyl-ingenane-3-angelate; when R is equal to H, the compound 2 is 5, 20-diacetyl-ingenane-3-angelate.

Description

technical field The present invention relates to the field of pharmaceutical compounds and pharmacy, specifically, compound 1 (5,17,20-triacetyl-ingenine-3-angelate) and compound 2 (5,20-diacetyl- Ingenue-3-angelate) is a pharmaceutical composition as an active ingredient, and its application in the preparation of medicines for treating or preventing tumor diseases. Background technique Angiogenesis is considered an absolute requirement for the growth of tumors larger than 1–2 mm. In tumors smaller than this limit, oxygen and nutrients can be delivered to the cells by diffusion. However, when a certain size is reached, each tumor is dependent on angiogenesis in order to continue growing. Tumor-initiating cells in hypoxic areas respond by stimulating VEGF production, which causes activation of resting endothelial cells to stimulate new blood vessel formation. Furthermore, VEGF in tumor areas without any angiogenesis can proceed through the ras signaling pathway. In situ h...

AI Technical Summary

Problems solved by technology

So far, compound 1 (5,17,20-triacetyl-ingen-3-angelate) and compound 2 (5,20-diacetyl-ingen-3- -angelate) has anti-tumor efficacy reports

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