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Tyrosine kinase inhibitors

A technology selected from, alkyl, applied in the field of 5H-benzo[4, which can solve the problems of excess biological and biochemical effects

Active Publication Date: 2012-11-14
MERCK SHARP & DOHME BV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Stimulation of MET via hepatocyte growth factor (also known as scatter factor, HGF / SF) is known to result in excess biological and biochemical effects in the cell

Method used

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Examples

Experimental program
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Effect test

preparation example Construction

preparation example

Embodiment 1

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PUM

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Abstract

The present invention relates to 5H-benzo[4,5]cyclohepta[ 1,2-b]pyridine derivatives of formula (I) that are useful for treating cellular proliferative diseases, for treating disorders associated with MET activity, and for inhibiting the receptor tyrosine kinase MET. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

Description

Background of the invention The present invention relates to 5H-K as inhibitors of tyrosine kinases, in particular the receptor tyrosine kinase MET, and for use in the treatment of cell proliferative disorders (e.g. cancer, hyperplasia), restenosis, cardiac hypertrophy, immune disorders and inflammation. Benzo[4,5]cyclohepta[1,2-b]pyridine compounds. Research on signal transduction pathways has yielded a variety of promising molecular targets for therapeutic inhibition in cancer treatment. Receptor tyrosine kinases (RTKs) represent an important class of such therapeutic targets. Members of the MET proto-oncogene family (receptor tyrosine kinase subfamily) are currently drawing particular attention to the link between invasion and metastasis. The MET family, which includes MET (also known as c-Met) and the RON receptor, functions as oncogenes like most tyrosine kinases. MET has been shown to be overexpressed and / or mutated in a variety of malignancies. Many MET-activating m...

Claims

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Application Information

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IPC IPC(8): C07D221/16C07D401/04C07D401/14C07D409/14C07D413/14C07D417/14C07D471/04C07D487/04C07D513/04A61K31/435A61P35/00
CPCC07D401/14C07D471/04C07D417/14C07D413/14C07D513/04C07D221/16C07D487/04C07D409/14C07D401/04A61P27/02A61P29/00A61P35/00A61P35/02A61P35/04A61P37/00A61P43/00A61P9/00A61K31/435
Inventor C·J·丁斯莫尔M·H·卡彻尔A·B·诺尔斯拉普
Owner MERCK SHARP & DOHME BV
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