Hydroxylapatite-bioglass film and preparation technology thereof

A technology of hydroxyapatite and biological glass, which is applied in metal material coating process, prosthesis, vacuum evaporation coating, etc., can solve the problems of mixing hydroxyapatite and 45S5 glass, preparing biological film, etc. Achieve good biocompatibility and good biocompatibility

Inactive Publication Date: 2009-10-07
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the preparation of biofilm by mixing hydroxyapatite and 45S5 glass

Method used

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  • Hydroxylapatite-bioglass film and preparation technology thereof
  • Hydroxylapatite-bioglass film and preparation technology thereof
  • Hydroxylapatite-bioglass film and preparation technology thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Embodiment 1: Preparation of hydroxyapatite-biological glass film, the process is as follows: the energy density is 5J-cm 2 The pulsed laser, with 50wt.% HA+50wt.% 45S5 as the target material, completed the film deposition under the conditions of substrate temperature 600 ℃, argon atmosphere, atmosphere pressure 45Pa, pulse number 18000.

Embodiment 2

[0043] Embodiment 2: Preparation of hydroxyapatite-biological glass film, the process is as follows: the energy density is 5J-cm 2 The pulsed laser, with 50wt.% HA+50wt.% 45S5 as the target material, completed the film deposition under the conditions of substrate temperature of 400°C, argon atmosphere, atmosphere pressure of 5Pa, and pulse number of 18000.

Embodiment 3

[0044] Embodiment 3: Preparation of hydroxyapatite-biological glass film, the process is as follows: the energy density is 5J-cm 2 The pulsed laser, with 50wt.% HA+50wt.% 45S5 as the target material, completed the film deposition under the conditions of substrate temperature of 200°C, argon atmosphere, atmosphere pressure of 20Pa, and pulse number of 9000.

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Abstract

The invention discloses a hydroxylapatite-bioglass film, which is prepared by taking hydroxylapatite or bioglass or the mixture of both as a target material and using the following technology of: adopting pulse laser with energy density of 5J-cm to complete the sedimentation of the film in an argon atmosphere with underlayer temperature of 15 DEG C to 600 DEG C and pressure of 5Pa to 45Pa or an oxygen atmosphere with pressure of 1*10-9*10Pa and under the condition with pulse number of 3,000-18,000. The bio-film has no cytotoxic effect and good biocompatibility, causes no hemolytic reaction and acute systemic toxicity effect, imposes no obvious inhibition on the growth and proliferation of cells, generates no toxic action to laboratory animals, and meets the requirements for biological safety.

Description

technical field [0001] The invention relates to a hydroxyapatite-biological glass film and a preparation process thereof. Background technique [0002] Biomedical materials (Biomedical Materials) refer to new materials used to combine with living systems to diagnose, treat, repair or replace damaged tissues and organs of living organisms or enhance their functions. As an important part of biomedical material research, the research on human implant materials has developed rapidly in recent decades, especially in the past two decades, and has become a focus in current medical research. [0003] At present, a variety of implant materials have been used clinically. Hydroxyapatite (HA) has become one of the most widely used clinical implant materials because of its good biocompatibility and bioactivity, and is widely present in hard tissues such as animal bones and teeth. However, the strength and toughness of bulk hydroxyapatite are poor, so it cannot be applied to the bearing...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/32C23C14/28C23C14/06A61L27/12A61L27/10A61L27/06
Inventor 陈传忠王佃刚于慧君马杰
Owner SHANDONG UNIV
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