Synthesis method of 3, 4-dihydroxy phenylethanol

Abstract

The invention relates to a synthesis method of 3, 4-dihydroxy phenylethanol. The method comprises the following steps of: a. synthesis of 3, 4-dibenzyloxy benzaldehyde; b. synthesis of 3, 4-dibenzyloxy hyacinthin; c. synthesis of 3, 4-dibenzyloxy phenylethylalcohol; and d. 3, 4-dihydroxy phenylethanol. The raw materials adopted by the method are low in price and available, the reaction steps are reasonable and simple; the reaction conditions are mild, and the side products are less; therefore, the synthesis method can be used for industrial production on large scale; the synthesis yield of 3,4-dihydroxy phenylethanol is high and can be more than 90 percent and the purity of the finished product is also high and can be more than 98 percent; the intermediate produced in the synthesis process is more stable, side reaction products are less, the intermediate can be purified easily and has high yield and purity and the obtained 3, 4-dihydroxy phenylethanol has high yield and purity.

Description

technical field [0001] The invention relates to a method for synthesizing phenolic compounds, in particular to a method for synthesizing 3,4-dihydroxyphenethyl alcohol; it belongs to the technical field of chemical industry. Background technique [0002] 3,4-Dihydroxyphenylethanol, common trade name: hydroxytyrosol; molecular formula: C 8 h 10 o 3 , English name: 3,4-Dihydroxyphenylethanol, molecular weight: 154.16. 3,4-Dihydroxyphenylethanol was first extracted from olive oil, which is relatively expensive and widely used. 1. It is mainly used in the synthesis of cardiovascular drugs: it has miraculous effects on the prevention and treatment of arteriosclerosis, hypertension, heart disease, and cerebral hemorrhage. 2. As a safe and efficient antioxidant: used in beauty products and health care products, it can effectively enhance skin elasticity and moisturization, and has the effect of anti-wrinkle and anti-aging. 3. Anti-aging is beneficial to the skeletal system: it ...

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Problems solved by technology

[0003] Chinese patent application (publication number: CN10129841A) relates to the method for extracting 3,4-dihydroxyphenylethanol from olive extract, and the method comprises the following steps: (1) adding deionized water to dilute the olive extract; Styrene resin chromatography column, rinse with deionized water, discard the effluent of the first 300ml-500ml, then start to receive the transparent eluent; (3) concentrate the transparent eluent, extract with ethyl acetate, and Concentrate the ethyl acetate layer, reclaim the ethyl acetate, and shrink to the point that it cannot be shrunk again to obtain a light orange jelly; (4) molecularly distill the light orange jelly to obtain the crude product of 3,4-dihydroxyphenylethanol, although the The method adopts the molecular distillation method, the operating temperature is low, the heating time of the extract is short, and the original quality of the natural product is maintained to the greatest extent; however, the content of 3,4-dihydroxyphenylethanol in the olive extract is low, and a certain amount of 3,4-dihydroxyphenylethanol is extracted. , 4-dihydroxyphenylethanol requires a large amount of olive extract, and there are many impurities in the olive extract and it is impossible to extract 3,4-dihydroxyphenylethanol with higher purity

[0009] Though the technological process of this method is simple, and reaction step is less; But raw material 2-chloro-1-(3,4-dihydroxy) acetophenone is not easy to obtain, and side reaction is more, and the gained product is difficult to purify, and the quality of product and the yield is not high

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