Effective part extract of valeriana amurensis P.Smirn. and quality control method and medical use thereof

An effective part, the technology of black water valerian, applied in the field of extracts of effective parts of valerian, can solve the problems of preparation method and quality control of anti-senile dementia of black water valerian

Inactive Publication Date: 2009-12-16
匡海学
View PDF0 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far there is no relevant report on the preparation method and qu...

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Effective part extract of valeriana amurensis P.Smirn. and quality control method and medical use thereof
  • Effective part extract of valeriana amurensis P.Smirn. and quality control method and medical use thereof
  • Effective part extract of valeriana amurensis P.Smirn. and quality control method and medical use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Take 5000g of black water valerian raw material, first extract 3 times with 50% ethanol which is 20 times the weight of the raw material, each extraction time is 1.5 hours, combine the above extracts, recover ethanol under reduced pressure to less than or equal to 15000ml, and obtain medicinal solution 1;

[0047] Suspend the medicinal solution 1 in water and then extract it with petroleum ether to obtain petroleum ether extract and aqueous medicinal solution 2;

[0048] The aqueous liquid medicine 2 is loaded to D101 type macroporous adsorption resin column chromatography D101 (resin weighs 80g, column volume 100ml, column diameter: column height=1: 2) to carry out adsorption, and the sample loading flow rate is 1.2 times column volume per hour, After loading the sample, rinse the column with distilled water until the water eluate is nearly colorless, discard the water eluate, and elute with 30% ethanol aqueous solution containing 6 times the column volume, and the flow...

Embodiment 2

[0051] Get 2500g of black water valerian root and rhizome coarse powder raw material, first extract 3 times with 70% ethanol of 20 times the weight of the raw material, each extraction time is 1.5 hours, combine the above extracts, reclaim the ethanol under reduced pressure to less than or equal to 7500ml, and obtain the medicine Liquid 1;

[0052] Suspend the medicinal solution 1 in water and then extract it with petroleum ether to obtain petroleum ether extract and aqueous medicinal solution 2;

[0053] AB-8 type macroporous adsorption resin column chromatography (resin weighs 80g, column volume 100ml, column diameter: column height=1:2) on the aqueous liquid medicinal liquid 2, flow velocity is 1.3 times of column volume per hour, after loading the sample, use Rinse the column with distilled water until the water eluate is nearly colorless, discard the water eluate, and elute with 6 times the column volume containing 40% ethanol, and the flow rate of the eluent is controlle...

Embodiment 3

[0056] Get 2000g of black water valerian root and rhizome coarse powder raw material, first extract 3 times with 95% ethanol of 20 times the weight of the raw material, each extraction time is 1.5 hours, combine the above extracts, combine the above extracts, and reclaim the ethanol under reduced pressure to less than or equal to 6000ml, to obtain liquid medicine 1;

[0057] Suspend the medicinal solution 1 in water and then extract it with petroleum ether to obtain petroleum ether extract and aqueous medicinal solution 2;

[0058] H103 type macroporous adsorption resin column chromatography H103 (resin weight 80g, column volume 100ml, column diameter: column height=1:2) on the aqueous solution liquid 2, flow rate is 1.1 times of column volume per hour, after loading the sample, use distilled water Rinse the column until the water eluate is nearly colorless, discard the water eluate, and elute with 6 times the column volume containing 50% ethanol, and the flow rate of the elue...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses an effective part extract of valeriana amurensis P.Smirn. and a quality control method and medical use thereof. The content of total lignanoid substances in the extract accounts for over 50 percent of the total weight of the extract, wherein (+) pinoresinol-4,4'-O-beta-D-diglucopyranoside and (+) pinoresinol-8-O-beta-D-glucopyranoside are the main active components in the effective part extract, and the sum of the contents of the two active components accounts for more than 13 percent of the total weight of the extract. The invention also discloses a preparation method and the quality control method of the effective part extract. The effective part extract contains one effective part group of total lignanoid components and can effectively treat central nervous system degenerative diseases including senile dementia, tristimania and the like. The process for preparing the effective part extracts of the valeriana amurensis P.Smirn. for resisting the senile dementia can adapt to industrial production, and provides a new method for treating the central nervous system degenerative diseases by using the valeriana amurensis P.Smirn..

Description

technical field [0001] The present invention relates to extracts from effective parts of Chinese herbal medicines, in particular to extracts from effective parts of Valeriana amurensis Smir. The use of part extracts in treating degenerative diseases of the central nervous system belongs to the field of effective part extracts of the genus Valeriana. Background technique [0002] Blackwater valerian is the dry root and rhizome of Valeriana amurensis Smir. Blackwater valerian is mainly distributed in Northeast China, and is rich in resources in the Greater Khingan Mountains. Plants of the same genus have been used to treat various diseases such as insomnia, and also have different pharmacological effects on the nervous system, cardiovascular and cerebrovascular, and anti-tumor. The latest research has found that the chemical components of Valeriana have beneficial effects on the neurodegenerative disease senile dementia. Therapeutic effect. But so far there is no relevant r...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K36/185A61P25/28A61P25/24A61K125/00
Inventor 匡海学王秋红左月明张忠立
Owner 匡海学
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap