Composition for improving brain function

A brain function improvement and composition technology, applied in the directions of drug combination, application, food science, etc., can solve the problems of not improving monoamine metabolism, not very strong, etc., and achieve the effects of excellent safety, improved function reduction, and improved metabolism

Inactive Publication Date: 2009-12-23
MITSUKAN GROUP CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] However, it has been reported that the brain function improving effects of phosphatidylcholine and phosphatidylserine, etc., are not so strong as they do not improve the metabolism of monoamines (see, for example, Non-Patent Documents 3 and 4).

Method used

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  • Composition for improving brain function
  • Composition for improving brain function
  • Composition for improving brain function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0084] Embodiment 1 (preparation of alkaline stable lipid derived from acetic acid bacteria)

[0085] Gluconacetobacter xylinus NBRC15237 strain as an acetic acid bacteria strain. This acetic acid bacterium strain is deposited in the Biogenetic Resources Division of the Biotechnology Headquarters (2-5-8, Kamiso Kamizu, Kisarazu City, Chiba Prefecture), and is a acetic acid bacterium that can be distributed.

[0086] Alkaline-stable lipids derived from acetic acid bacteria were prepared as follows.

[0087] That is, 2000 g of dried cells of the acetic acid bacterial strain were extracted with a chloroform-methanol solvent (chloroform:methanol:water=1:2:0.8), and then the two layers were separated, and the lower layer was recovered as a total lipid fraction. Then, use 0.4N NaOH to decompose the whole lipid fraction with weak alkaline to remove phospholipids, re-extract according to the composition of Folch (chloroform: methanol: water = 8: 4: 3), concentrate and dry, and obtain...

Embodiment 2

[0095] Embodiment 2 (using memory impairment model mice, the improvement effect produced in the Morris water maze test by the administration of alkaline stable lipid derived from acetic acid bacteria)

[0096] The degeneration and shedding of cholinergic nerves are found in the Meynert nucleus at the base of the forebrain in the brains of AD patients and aged brains, and can be induced by administering ibotenic acid (ibotenic acid) in the brains of normal rats. Same phenomenon. Then, according to the conventional method, 5 μg of neurotoxin ibotenic acid was injected into the basal forebrain Meynert nucleus of 7-week-old Crj:Wister male rats to prepare memory impairment model rats with cholinergic nerve shedding .

[0097] An acetylcholinesterase inhibitor approved as a therapeutic agent for AD is reported to show improvement in learning ability in behavioral tests by oral administration in this memory impairment model rat.

[0098] In this memory-impaired rat, 14 days from t...

Embodiment 3

[0131] Example 3 (Amelioration Effect of Monoamine Content in Brain by Administration of Basic Stable Lipid Derived from Acetobacter in Rats Using Memory Impairment Model)

[0132] The concentration of monoamines such as norepinephrine and serotonin in the forebrain cortex and hippocampus decreases with the shedding of cholinergic nerves in the Meynert nucleus at the base of the forebrain, which is found in the brains of AD patients and aged brains. The relationship between abnormal metabolism of monoamine compounds and various neurological and mental diseases has been clarified.

[0133] Then, with respect to each group of rats in Example 2, the changes of the substances in their brains were measured.

[0134] That is, the brain of the model rat with memory impairment prepared in Example 2 was extracted, and the content of monoamine in the forebrain cortex and hippocampus was measured.

[0135] (1) Determination of monoamine content in memory impairment model rat brain

[0...

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Abstract

Provided is a substance which is a safe material such as a food component and an extract of a natural product and has a stronger effect of ameliorating a cerebral function (effect of ameliorating a metabolism of monoamines as an intracerebral neurotransmitter and ameliorating deterioration in memory and learning due to hypofunction of a cholinergic neuron). The present invention provides a composition for ameliorating a cerebral function, comprising an alkali-stable lipid from an acetic acid bacterium, N-acylsphinganine or N-2'-hydroxypalmitoyl-sphinganine, as an active ingredient.

Description

technical field [0001] The present invention relates to a functional composition having an effect of improving brain function by oral ingestion. More specifically, the present invention relates to alkaline stable lipid (alkali-stable lipid), N-acyl dihydrosphinganine (N-acylsphinganine) or N-2'-hydroxy palmitoyl-di A composition for improving brain function which has functions of improving memory and learning ability by improving abnormality of neurotransmission mechanism with hydrosphingosine as an active ingredient. Background technique [0002] In recent years, along with the aging of the population, neurological and psychiatric diseases have placed an increasing burden on society. For example, learning and memory impairments caused by dementia, which is more common in the elderly, have become serious problems. The number of dementia patients in Japan has exceeded 1 million, and it is said that the number will increase to nearly 3 million in 20 years. [0003] It is kno...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/164A61K35/74A61P25/28
CPCA61K31/164A23L1/3006A23L1/30C12J1/00A61K35/74A23L33/10A23L33/115A61P25/28
Inventor 深见裕之
Owner MITSUKAN GROUP CORP
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