Composition for improving brain function
A brain function improvement and composition technology, applied in the directions of drug combination, application, food science, etc., can solve the problems of not improving monoamine metabolism, not very strong, etc., and achieve the effects of excellent safety, improved function reduction, and improved metabolism
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Embodiment 1
[0084] Embodiment 1 (preparation of alkaline stable lipid derived from acetic acid bacteria)
[0085] Gluconacetobacter xylinus NBRC15237 strain as an acetic acid bacteria strain. This acetic acid bacterium strain is deposited in the Biogenetic Resources Division of the Biotechnology Headquarters (2-5-8, Kamiso Kamizu, Kisarazu City, Chiba Prefecture), and is a acetic acid bacterium that can be distributed.
[0086] Alkaline-stable lipids derived from acetic acid bacteria were prepared as follows.
[0087] That is, 2000 g of dried cells of the acetic acid bacterial strain were extracted with a chloroform-methanol solvent (chloroform:methanol:water=1:2:0.8), and then the two layers were separated, and the lower layer was recovered as a total lipid fraction. Then, use 0.4N NaOH to decompose the whole lipid fraction with weak alkaline to remove phospholipids, re-extract according to the composition of Folch (chloroform: methanol: water = 8: 4: 3), concentrate and dry, and obtain...
Embodiment 2
[0095] Embodiment 2 (using memory impairment model mice, the improvement effect produced in the Morris water maze test by the administration of alkaline stable lipid derived from acetic acid bacteria)
[0096] The degeneration and shedding of cholinergic nerves are found in the Meynert nucleus at the base of the forebrain in the brains of AD patients and aged brains, and can be induced by administering ibotenic acid (ibotenic acid) in the brains of normal rats. Same phenomenon. Then, according to the conventional method, 5 μg of neurotoxin ibotenic acid was injected into the basal forebrain Meynert nucleus of 7-week-old Crj:Wister male rats to prepare memory impairment model rats with cholinergic nerve shedding .
[0097] An acetylcholinesterase inhibitor approved as a therapeutic agent for AD is reported to show improvement in learning ability in behavioral tests by oral administration in this memory impairment model rat.
[0098] In this memory-impaired rat, 14 days from t...
Embodiment 3
[0131] Example 3 (Amelioration Effect of Monoamine Content in Brain by Administration of Basic Stable Lipid Derived from Acetobacter in Rats Using Memory Impairment Model)
[0132] The concentration of monoamines such as norepinephrine and serotonin in the forebrain cortex and hippocampus decreases with the shedding of cholinergic nerves in the Meynert nucleus at the base of the forebrain, which is found in the brains of AD patients and aged brains. The relationship between abnormal metabolism of monoamine compounds and various neurological and mental diseases has been clarified.
[0133] Then, with respect to each group of rats in Example 2, the changes of the substances in their brains were measured.
[0134] That is, the brain of the model rat with memory impairment prepared in Example 2 was extracted, and the content of monoamine in the forebrain cortex and hippocampus was measured.
[0135] (1) Determination of monoamine content in memory impairment model rat brain
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