Composition for treatment of pancreatic cancer

A composition and compound technology, applied in the directions of drug combinations, active ingredients of heterocyclic compounds, medical preparations containing active ingredients, etc., can solve problems such as no reports and the like

Inactive Publication Date: 2009-12-30
EISIA R&D MANAGEMENT CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, there is no report on whether a pharmaceutical composition composed of the above-mentioned substances exhibits an antitumor effect

Method used

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  • Composition for treatment of pancreatic cancer
  • Composition for treatment of pancreatic cancer
  • Composition for treatment of pancreatic cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0232] [Example 1] Combined use of the compound of the present invention and gemcitabine hydrochloride in a human pancreatic cancer cell line (AsPC-1) subcutaneous transplantation model (in vivo)

[0233] Human pancreatic cancer cell line AsPC-1 (purchased from ATCC) was cultured with RPMI1640 (containing 10% FBS) in a 5% carbon dioxide incubator at 37°C to about 80% confluent, and the cells were recovered by trypsin-EDTA . Prepare 5 x 10 with phosphate buffer 7 cells / mL of the suspension, and the obtained cell suspension was subcutaneously transplanted into the side of nude mice in an amount of 0.1 mL per mouse. From day 11 after transplantation, 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-carbamoylquinoline or gemcitabine (purchased from Eli Lilly Japan), or a combination of both, wherein 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy) was orally administered once daily at a dosage of 3, 10 or 30 mg / kg Base)-7-methoxyl-6-carbamoylquinoline, use...

Embodiment 2

[0247] [Example 2] Combined use of the compound of the present invention and erlotinib hydrochloride in a human pancreatic cancer cell line (AsPC-1) subcutaneous transplantation model (in vivo)

[0248] The human pancreatic cancer cell line AsPC-1 (purchased from ATCC) was cultured with RPMI1640 (containing 10% FBS) in a 5% carbon dioxide incubator at 37°C to a confluence of about 80%, and the cells were recovered by trypsin-EDTA. Prepare 5 x 10 in phosphate buffer 7 cells / mL of the suspension, and the obtained cell suspension was subcutaneously transplanted into the side of nude mice in an amount of 0.1 mL per mouse. Oral administration of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-carbamoylquinoline or errotide alone from day 10 after transplantation Nitrate hydrochloride, or a combination of oral administration of the two, wherein, 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-carbamoylquinoline Each administration is 10 mg / kg, a...

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PUM

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Abstract

Disclosed are a pharmaceutical composition having excellent antitumor activity, and a method for treating a cancer. Specifically, excellent antitumor activity is achieved when 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7- methoxy-6-quinolinecarboxamide or an analogous compound thereof, a pharmacologically acceptable salt thereof or a solvate of any of them is used in combination with gemcitabine or erlotinib, a pharmacologically acceptable salt thereof or a solvate of any of them.

Description

technical field [0001] The present invention relates to the following pharmaceutical composition and kit, as well as a method for treating cancer characterized by administering an effective amount of the pharmaceutical composition to a patient, the use of the compound of the present invention in the manufacture of the pharmaceutical composition, and its use in the pharmaceutical composition. The compound of the present invention of the above-mentioned pharmaceutical composition etc., described pharmaceutical composition is represented by the compound of general formula (I), or its pharmacologically acceptable salt, or their solvate (hereinafter also referred to as " compound of the present invention ”) and gemcitabine (gemcitabine) or erlotinib (erlotinib), or a pharmacologically acceptable salt thereof, or a solvate thereof. Background technique [0002] Substances used so far as chemotherapeutic agents for cancer include the alkylating agent cyclophosphamide, the metabolic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/47A61K31/517A61K31/7068A61P35/00C07D215/48
CPCC07D407/04C07D239/94C07D215/20A61K31/47A61K31/7068A61K31/517A61P35/00A61P35/02A61P43/00A61K2300/00A61K31/4409A61K31/505
Inventor 山本裕之
Owner EISIA R&D MANAGEMENT CO LTD
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