Salts of 3-(3-amino-2-(r)-hydroxy-propyl)-1-(4-fluoro-phenyl)-8-(8-methyl-naphthalen-1-ylmethyl)-1,3,8-triaza-spiro[4.5]decan-4-one

A technology of sulfates and compounds, which can be used in medical preparations containing active ingredients, metabolic diseases, drug combinations, etc., and can solve problems such as low affinity
CN101622254BInactive Publication Date: 2013-05-29JANSSEN PHARMA NV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
JANSSEN PHARMA NV
Publication Date
2013-05-29
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention is directed to salts of 3-(3-amino-2-(R)-hydroxy-propyl)-1-(4-fluoro-phenyl)-8-(8-methyl-naphthalen-1-ylmethyl)-1,3,8-triaza-spiro[4.5]decan-4-one, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by NOP, for example depression, anxiety, alcohol abuse, etc. The present invention is further directed to process(es) for the preparation of 3-(3-amino-2-(R)-hydroxy-propyl)-1-(4-fluoro-phenyl)-8-(8-methyl-naphthalen-1-ylmethyl)-1,3,8-triaza-spiro[4.5]decan-4-one and its corresponding salts.
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Description

[0001] Cross References to Related Applications

[0002] This application claims the benefit of US Provisional Patent Application Serial No. 60 / 861,378, filed November 28, 2006, which is hereby incorporated by reference in its entirety. field of invention

[0003] The present invention relates to 3-(3-amino-2-(R)-hydroxy-propyl)-1-(4-fluoro-phenyl)-8-(8-methyl-naphthalen-1-ylmethyl)- Salts of 1,3,8-triaza-spiro[4.5]decan-4-one, pharmaceutical compositions comprising said salts and their use in the treatment of diseases and conditions modulated by NOP. The present invention further relates to the preparation of 3-(3-amino-2-(R)-hydroxy-propyl)-1-(4-fluoro-phenyl)-8-(8-methyl-naphthalen-1-ylmethyl )-1,3,8-triaza-spiro[4.5]decane-4-one and 3-(3-amino-2-(R)-hydroxyl-propyl)-1-(4-fluoro-benzene base)-8-(8-methyl-naphthalen-1-ylmethyl)-1,3,8-triaza-spiro[4.5]decane-4-one salt method. Background of the invention

[0004] ORL-1 (orphan opioid receptor) G protein-coupled receptor...

Claims

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