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Moguisteine dried suspension and preparation method thereof

A technology of suspensions and suspending agents, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, drug delivery, etc., and can solve the problems of low bioavailability of oral solid preparations, melting of mogisteine, poor taste of patients, etc. problem, to achieve the effect of good compliance, good absorption and fast absorption

Inactive Publication Date: 2011-11-23
广州达信生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the low solubility of mogisteine ​​in water easily leads to low bioavailability of the oral solid preparation
Moreover, mogisteine ​​tastes bitter, and the patient's taste is poor when taken orally.
Therefore, it is necessary to solve the problem of mogistein melting during the preparation process, as well as the problems of low dissolution rate and poor mouthfeel, so that it can be prepared into an oral preparation suitable for clinical use

Method used

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  • Moguisteine dried suspension and preparation method thereof
  • Moguisteine dried suspension and preparation method thereof

Examples

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preparation example Construction

[0025] The preparation method of the present invention preferably further includes: before step (1), passing the mogisteine ​​through a 120-mesh sieve, and passing the suspending agent, filler and sweetener through a 100-mesh sieve.

[0026] In the preparation method of the present invention, the mixing in step (1) is preferably carried out by crossing a 60 mesh-80 mesh sieve; the granulation in step (3) is preferably carried out by crossing a 18-24 mesh sieve; step ( 4) The drying in 4) is preferably carried out by blast drying at 40°C until the water content in the granules is less than or equal to 1 part by weight; the granulation in step (5) is preferably carried out by passing the dried granules 18-24 mesh sieve, then pass through a 50 mesh sieve.

[0027] The wetting agent is preferably 40%-60% by volume ethanol in water.

[0028]In the preparation method of the present invention, before the mogistein and other auxiliary materials are sieved as described above, these ma...

Embodiment 1

[0043] Mogistein was sieved through a 120-mesh sieve, and other excipients (including sodium carboxymethylcellulose, lactose, microcrystalline cellulose, and sucrose) were sieved through a 100-mesh sieve.

[0044] Then, the mogisteine ​​of 100g gained is used as principal agent, and the sodium carboxymethylcellulose of 100g gained is as suspending agent, the lactose of 100g gained and the microcrystalline cellulose of 50g gained are as filler, and the sucrose of 50g gained as a sweetener. Pass these materials through a 60-80 mesh sieve and mix evenly.

[0045] Add 100ml of 50% by volume aqueous ethanol as a wetting agent and add 5g of orange essence soft material in the resulting mixture, cross 24 mesh sieves and granulate, and blow dry at 40°C until the water content in the material obtained is less than or It is equal to 1% by weight, and then the material is passed through a 18-mesh sieve for granulation, and then passed through a 50-mesh sieve to obtain the mogisteine ​​d...

Embodiment 2

[0047] Prepare the mogisteine ​​dry suspension of embodiment 2 according to the same method as example 1, the difference is that 100g mogisteine ​​is used as the main ingredient, 100g carboxymethylcellulose sodium is used as the suspending agent, 200g lactose As a bulking agent, 30 g of sucrose as a sweetener and 5 g of orange essence as a essence, and a 50 volume % ethanol aqueous solution of 150 ml is used as a wetting agent.

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Abstract

The invention relates to a moguisteine dried suspension and a preparation method thereof. The moguisteine dried suspension comprises the following components in portion by weight: 5 to 45 portions of moguisteine, 2 to 40 portions of suspending agent, 5 to 80 portions of filling agent, 1 to 30 portions of sweetening agent, and 0.5 to 5 portions of essence. The moguisteine dried suspension has the advantages of high dispersity, even distribution, quick absorption, high bioavailability, good adaptability, good mouthfeel, stability and the like. The moguisteine dried suspension can be applied to cough relief.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to a mogistein dry suspension and a preparation method thereof. Background technique [0002] Coughing is an important reflex protection mechanism. Coughing can expel sputum and foreign objects in the respiratory tract, protect the cleanliness and smoothness of the respiratory tract, and prevent infection. However, if the severe cough persists, not only the patient suffers, but also other complications are likely to occur. With the aging of society and the aggravation of environmental pollution, the incidence of respiratory diseases continues to rise. Expectorant and antitussive drugs will be an important part of respiratory system drugs, so it is necessary to choose appropriate antitussives to relieve cough. [0003] Moguisteine ​​(moguisteine) is an acetylcholine antagonist developed by Swiss Roche Company, a peripheral non-narcotic antitussive drug, which has no effect on the central ner...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K9/14A61K31/426A61P11/14
Inventor 陈宝林雍智全阴元魁陈皓赖观平韩为跃闻亚磊
Owner 广州达信生物技术有限公司